Deeper Knowledge, Faster

  • Predict branded drug patent expiration
  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Harvard Business School
Federal Trade Commission
US Department of Justice

Generated: July 20, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,814,335

« Back to Dashboard

Claims for Patent: 5,814,335

Title: Sphingosomes for enhanced drug delivery
Abstract:Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
Inventor(s): Webb; Murray S. (Vancouver, CA), Bally; Marcel B. (Bowen Island, CA), Mayer; Lawrence D. (N. Vancouver, CA), Miller; James J. (Vancouver, CA), Tardi; Paul G. (Richmond, CA)
Assignee: Inex Pharmaceuticals Corporation (CA)
Application Number:08/932,375
Patent Claims: 1. A liposome for delivery of an alkaloid therapeutic compound, produced by the process of:

forming a liposome from a mixture which comprises sphingomyelin and cholesterol, in a first buffered aqueous solution having an acidic pH greater than pH 2; and

suspending the liposome in a second buffered solution having a pH which is greater than that of the first buffered aqueous solution, whereby a transmembrane pH gradient is formed which facilitates the transfer of the therapeutic compound to the liposome.

2. The liposome produced by the process of claim 1, wherein the process further comprises the step of separating the liposome containing the therapeutic compound from the second buffer containing therapeutic compound which has not been entrapped by the liposome.

3. A liposome of claim 1, wherein the cholesterol is present in the liposomal composition at a total molar proportion of 30% to 50%.

4. A liposome of claim 1, wherein the sphingomyelin and cholesterol are present at a ratio of about 55/45, mol %/mol %, respectively.

5. A liposome of claim 1, wherein the alkaloid compound is vincristine or swainsonine.

6. A liposome of claim 1, wherein the alkaloid compound is vincristine.

7. A liposome of claim 1, wherein the alkaloid compound is swainsonine.

8. A liposome of claim 1, wherein the liposomes are unilamellar.

9. A liposome of claim 1, wherein the liposomes have mean diameters of about 0.05 microns to 0.45 microns.

10. A liposome of claim 1, wherein the liposomes have mean diameters of about 0.05 microns to 0.2 microns.

11. A liposome of claim 1, wherein the interior of said liposome is pH 2 to pH 5.

12. A liposome of claim 1, wherein the interior comprises a citrate buffer at about pH 4.0.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
Farmers Insurance
Cantor Fitzgerald
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics

Follow DrugPatentWatch:

Google Plus