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Last Updated: April 26, 2024

Claims for Patent: 5,804,570

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Summary for Patent: 5,804,570

Title:	Method of lessening the risk of non-vertebral bone fractures
Abstract:	Alendronate, a bisphosphonate, when administered daily over a substantial period of time, can reduce the rate of non-vertebral fractures, in post-menopausal women.
Inventor(s):	Santora, II; Arthur C. (Watchung, NJ), Karpf; David B. (North Brunswick, NJ), Polvino; William J. (Bridgewater, NJ), Shapiro; Deborah Ruth (Edison, NJ), Thompson; Desmond E. (Martinsville, NJ), Yates; Ashley John (Westfield, NJ)
Assignee:	Merck & Co., Inc. (Rahway, NJ)
Application Number:	08/867,987
Patent Claims:	1. A method of reducing the risk of non-vertebral fractures in an osteoporotic female comprising administering an effective amount of alendronate or a pharmaceutically acceptable salt thereof. 2. The method according to claim 1 wherein the alendronate is administered orally. 3. The method according to claim 2 wherein the dose is from 2.5 mg to 20 mg daily. 4. The method according to claim 3 wherein the dose is 10 mg daily. 5. The method according to claim 2 wherein the alendronate is administered substantially daily for a period of more than two years. 6. The method according to claim 2 wherein the alendronate is administered substantially daily for a period of at least about three years. 7. The method according to claim 1 wherein the female is elderly. 8. A method of reducing the risk of non-vertebral bone fractures in an osteoporotic postmenopausal female comprising administering to the female from 2.5-20 mg of alendronate or a pharmaceutically acceptable salt thereof substantially daily for a substantial period of time. 9. A method according to claim 8 wherein the female is elderly. 10. The method according to claim 1 wherein the alendronate is administered for a substantial period of time. 11. The method according to claim 3 wherein the dose is 2.5 mg daily. 12. The method according to claim 3 wherein the dose is 5 mg daily. 13. The method according to claim 8 wherein the dose is 2.5 mg daily. 14. The method according to claim 8 wherein the dose is 5 mg daily. 15. The method according to claim 8 wherein the dose is 10 mg daily. 16. The method according to claim 8 wherein the dose is 20 mg daily.

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