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Claims for Patent: 5,800,807

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Claims for Patent: 5,800,807

Title: Ophthalmic compositions including glycerin and propylene glycol
Abstract:There are disclosed ophthalmic compositions having high water-binding properties which are useful as: moisturizing and lubricating (i.e. artificial tear) solutions, dry eye therapies, contact lens wetting and lubricating solutions, and as delivery vehicles for ophthalmic drugs. The subject compositions include glycerin in combination with propylene glycol. The subject compositions may further include cellulose derivatives, e.g. hydroxypropyl methyl cellulose, along with preservatives, e.g. benzylalkonium chloride, PHMB, sorbic acid, etc. Preferred compositions have at least 11% bound water, a pH from about 7.1 to 7.5, and an osmolality between about 280 to about 320 mOsm/Kg.
Inventor(s): Hu; Zhenze (Pittsford, NY), Denick; John (Pittsford, NY)
Assignee: Bausch & Lomb Incorporated (Rochester, NY)
Application Number:08/794,690
Patent Claims: 1. An ophthalmic composition comprising:

(a) from about 0.2 to 1.5 weight percent of glycerin, and

(b) from about 0.2 to 1.5 weight percent of propylene glycol, wherein said solution has an osmolality of between about 175 and 330 mOsm/kg and a pH from 6.0 to 8.0.

2. The composition of claim 1 including at least one of: a cellulose derivative, dextran, gelatin, polyethylene glycol, polysorbate, polyvinyl alcohol and polyvinyl-pyrrolidone.

3. The composition of claim 2 including at least one cellulose derivative selected from the group: hydroxypropyl methyl cellulose, carboxymethyl cellulose, methyl cellulose, and hydroxyethyl cellulose.

4. The composition of claim 1 including a preservative.

5. The composition of claim 4 including at least one preservative selected from the group: benzylalkonium chloride, polyquat, PHMB, and sorbic acid.

6. The composition of claim 1 having a pH from about 7.1 to about 7.5, an osmolality between about 280 to about 320 mOsm/Kg, and at least about 11 percent bound water.

7. An ophthalmic solution useful as an artificial tear comprising:

(a) from about 0.2 to about 1.5 weight percent of glycerin,

(b) from about 0.2 to about 1.5 weight percent of propylene glycol,

(c) from about 0.2 to 3.0% of a cellulose derivative, and

(d) a borate buffer, and

wherein said solution has an osmolality between about 280 to about 320 MOsm/Kg, and a pH from about 7.1 to about 7.5.

8. The solution of claim 7 which excludes polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyethylene oxide, polyacrylic acid, anionic polymers.

9. A method for moisturizing or lubricating the eye by contacting the eye with an ophthalmic composition comprising:

(a) from about 0.2 to 1.5 weight percent of glycerin, and

(b) from about 0.2 to 1.5 weight percent of propylene glycol, wherein said solution has an osmolality of between about 175 and 330 mOsm/kg and a pH from 6.0 to 8.0.

10. An ophthalmic composition comprising a combination of demulcents consisting essentially of:

(a) from about 0.2 to 1.5 weight percent of glycerin, and

(b) from about 0.2 to 1.5 weight percent of propylene glycol, wherein said solution has an osmolality of between about 175 and 330 mOsm/kg and a pH from 6.0 to 8.0.
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