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Claims for Patent: 5,795,864

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Claims for Patent: 5,795,864

Title: Stable omega conopetide formulations
Abstract:Disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention.
Inventor(s): Amstutz; Gary Arthur (San Jose, CA), Bowersox; Stephen Scott (Menlo Park, CA), Gohil; Kishorchandra (Richmond, CA), Adriaenssens; Peter Isadore (Mountain View, CA), Kristipati; Ramasharma (Fremont, CA)
Assignee: Neurex Corporation (Menlo Park, CA)
Application Number:08/496,847
Patent Claims: 1. A stable omega conopeptide formulation comprising an omega conopeptide and an anti-oxidant composition capable of preventing methionine oxidation.

2. The formulation of claim 1, wherein the anti-oxidant composition includes a carboxylic acid buffer.

3. The formulation of claim 2, wherein the carboxylic acid buffer is lactate buffer.

4. The formulation of claim 1, wherein the anti-oxidant is methionine.

5. The formulation of claim 1, wherein the anti-oxidant composition includes lactate buffer and methionine.

6. An omega-conopeptide SNX-273 having the sequence: SEQ ID NO: 35.

7. An omega conopeptide SNX-279 having the sequence SEQ ID NO: 36.
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