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Generated: September 24, 2017

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Title: Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan
Abstract:The subject invention relates to pharmaceutical composition of R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof.
Inventor(s): Youdim; Moussa B. H. (Haifa, IL), Finberg; John P. M. (Tivon, IL), Levy; Ruth (Tel-Aviv, IL), Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Berger-Paskin; Tirtsah (Raanana, IL), Yellin; Haim (Ramat-Gan, IL), Veinberg; Alex (Rehovot, IL)
Assignee: Teva Pharmaceutical Industries Ltd. (Jerusalem, IL) Technion Research and Development Foundation Ltd. (Haifa, IL)
Application Number:08/470,161
Patent Claims: 1. A pharmaceutical composition which consists essentially of a therapeutically effective amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier is a solid and the pharmaceutical composition is a tablet.

3. The pharmaceutical composition of claim 2, wherein the therapeutically effective amount is an amount from about 0.1 mg to about 100 mg.

4. The pharmaceutical composition of claim 3, wherein the therapeutically effective amount is an amount from about 1 mg to about 10 mg.

5. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier is a liquid and the pharmaceutical composition is an injectable solution.

6. The pharmaceutical composition of claim 5, wherein the therapeutically effective amount is an amount from about 0.1 mg/ml to about 100 mg/ml per dosage unit.

7. The pharmaceutical composition of claim 6, wherein the therapeutically effective amount is an amount from about 1 mg/ml to about 10 mg/ml per dosage unit.

8. The pharmaceutical composition of claim 1, wherein the carrier is a gel and the pharmaceutical composition is a suppository.

9. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable salt is a mesylate salt.

10. A pharmaceutical composition which consists essentially of a therapeutically effective amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of Levodopa, and a pharmaceutically acceptable carrier.

11. The pharmaceutical composition of claim 10, wherein the therapeutically effective amount of R(+)-N-propargyl-1-aminoindan is about 0.1 mg to about 100 mg, and the therapeutically effective amount of Levodopa is about 50 mg to about 250 mg.

12. The pharmaceutical composition of claim 10, wherein the therapeutically effective amount of R(+)-N-propargyl-1-aminoindan is about 0.1 mg to about 100 mg, and the therapeutically effective amount of Levodopa is about 50 mg to about 200 mg.

13. A pharmaceutical composition which consists essentially of a therapeutically effective amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of a decarboxylase inhibitor, and a pharmaceutically acceptable carrier.

14. The pharmaceutical composition of claim 13, wherein the decarboxylase inhibitor is L-Carbidopa.

15. The pharmaceutical composition of claim 13, wherein the decarboxylase inhibitor is benserazide.

16. The pharmaceutical composition of claim 13, wherein the therapeutically effective amount of R(+)-N-propargyl-1-aminoindan is about 0.1 mg to about 100 mg, and the therapeutically effective amount of the decarboxylase inhibitor is about 10 mg to about 25 mg.

17. The pharmaceutical composition of claim 16, wherein the decarboxylase inhibitor is L-Carbidopa.

18. The pharmaceutical composition of claim 13, wherein the therapeutically effective amount of R(+)-N-propargyl-1-aminoindan is about 0.1 mg to about 100 mg, and the therapeutically effective amount of the decarboxylase inhibitor is about 12.5 mg to about 50 mg.

19. The pharmaceutical composition of claim 18, wherein the decarboxylase inhibitor is benserazide.
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