.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 5,776,885

« Back to Dashboard

Claims for Patent: 5,776,885

Title: Sustained and controlled release of water insoluble polypeptides
Abstract:A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such polymers and a therapeutically active peptide in the form of its pamoate, tannate or stearate salt. The composition when placed in an aqueous physiological environment releases the peptide in a continuous manner for a period of at least about one week.
Inventor(s): Orsolini; Piero (Martigny, CH), Mauvernay; Rolland-Yves (Lausanne, CH), Deghenghi; Romano (Lausanne, CH)
Assignee: Debio Recherche Pharmaceutique SA (Martigny, CH)
Application Number:08/196,872
Patent Claims: 1. A dry pharmaceutical composition designed for sustained release of a water-insoluble peptide salt comprising a polylactide polymer, a polymer of lactic and glycolic acid, or a mixture of said polymers and a therapeutically active peptide in the form of its pamoate salt, which composition, when placed in an aqueous physiological environment, releases the peptide in a continuous manner for a period of at least one week followed by maintenance of activity of the peptide for at least one month.

2. A pharmaceutical composition as claimed in claim 1 in which the peptide salt is the pamoate salt of LHRH or a synthetically prepared analogue thereof.

3. A pharmaceutical composition as claimed in claim 1 in which the peptide is a pharmaceutically acceptable salt of oxytocin, vasopressin, ACTH, calcitonin, epidermal growth factor, prolactin, inhibin, interferon, somatostatin, insulin, glucagon, atrial natriuretic factor, endorphin, a renin inhibitor, growth hormone releasing hormone, peptide T or a synthetic analogue thereof.

4. A pharmaceutical composition as claimed in claim 1 in which the peptide salt is the pamoate salt of D-Trp.sup.6 -LHRH.

5. A pharmaceutical composition as claimed in claim 1 in which the peptide salt is the pamoate salt of D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH.sub.2.

6. A pharmaceutical composition as claimed in claim 1 wherein the composition is in the form of particles ranging in size from 1 to 500 .mu.m.

7. A pharmaceutical composition as claimed in claim 1 in the form of a solid rod which is sterilized by gamma radiation.

8. A pharmaceutical composition as claimed in claim 1 wherein not more than 30% of the total amount of peptide is initially released during the first twenty-four hours.

9. A pharmaceutical composition as claimed in claim 1 in the form of a rod for use as a parenteral implant.

10. A pharmaceutical composition designed for sustained release of a peptide comprising a polylactide polymer, a polymer of a lactic and glycolic acid, or a mixture of said polymers and a therapeutically active peptide in the form of a water-insoluble pamoate salt, which composition, when placed in an aqueous physiological environment, releases the peptide in a continuous manner for a period of at least one week followed by maintenance of activity of the peptide for at least one month, wherein said pharmaceutical composition has been sterilized with gamma radiation and suspended in a pharmaceutically acceptable carrier.

11. A pharmaceutical composition as claimed in claim 10, wherein the peptide salt is dispersed within solid particles of the polymer.

12. A pharmaceutical composition as claimed in claim 11 wherein the peptide salt is the pamoate salt of D-Trp.sup.6 -LHRH, and the polymer is a D,L-lactide and glycolide polymer.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc