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Claims for Patent: 5,760,090

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Claims for Patent: 5,760,090

Title: Method for treating asthma using optically pure R(-) albuterol
Abstract:The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.
Inventor(s): Barberich; Timothy J. (Concord, MA), Young; James W. (Still River, MA)
Assignee: Sepracor, Inc. (Marlborough, MA)
Application Number:08/691,604
Patent Claims: 1. A method of treating asthma, while reducing side effects associated with the administration of racemic albuterol, comprising administering to an individual suffering from asthma a quantity of an optically pure R(-) isomer of albuterol sufficient to result in bronchodilation while simultaneously reducing undesirable side effects, said R isomer being substantially free of its S(+) isomer.

2. A method according to claim 1, wherein the albuterol comprises at least 90% by weight of the R(-) isomer and not more than 10% by weight of the S(+) isomer.

3. A method according to claim 1, wherein the albuterol comprises at least 99% by weight of the R(-) isomer and 1% or less by weight of the S(+) isomer.

4. A method according to claim 1, wherein the optically pure R(-) albuterol is administered by inhalation.

5. A method according to claim 4, wherein the optically pure R(-) albuterol is administered in an amount of about 30 .mu.g to about 90 .mu.g.

6. A method according to claim 1, wherein the optically pure R(-) albuterol is administered orally.

7. A method according to claim 6, wherein the optically pure R(-) albuterol is administered in an amount of about 1 mg to about 8 mg.

8. A method according to claim 6, wherein the optically pure R(-) albuterol is administered as a syrup.

9. A method according to claim 7, wherein the optically pure R(-) albuterol is administered as a syrup.
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