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|Title:||Vision through photodynamic therapy of the eye|
|Abstract:||Photodynamic therapy of conditions of the eye, especially those conditions characterized by unwanted neovasculature, such as age-related macular degeneration, results in enhanced visual acuity for treated subjects,|
|Inventor(s):||Strong; H. Andrew (North Van., CA), Levy; Julia (Vancouver, CA), Huber; Gustav (Zurich, CH), Fsadni; Mario (Buelach, CH)|
|Assignee:||QLT Phototherapeutics Inc (Vancouver, CA)|
1. A method to improve visual acuity in a human subject, which method comprises:
irradiating target ocular tissue in said subject with light emitted from a laser,
wherein said subject has been administered a formulation of a photoactive compound sufficient to permit an effective amount to localize in said target ocular tissue;
wherein the wavelength of the radiation is absorbed by the photoactive compound; and
wherein said radiation is conducted for a time and at an intensity sufficient to improve visual acuity in said subject.
2. The method of claim 1 wherein said irradiation is administered at an irradiance of about 600 mW/cm.sup.2 to provide a total fluence of 50 J/cm.sup.2 -150 J/cm.sup.2 of said light.
3. The method of claim 1 wherein said irradiation is administered beginning about 20-30 minutes after said subject has been administered said formulation.
4. The method of claim 1 wherein the eye of said subject contains unwanted neovasculature.
5. The method of claim 4 wherein the neovasculature is choroidal neovasculature.
6. The method of claim 1 wherein the photoactive agent is a green porphyrin, a hematoporphyrin derivative, a chlorin, or a phlorin.
7. The method of claim 6 wherein said photoactive compound is a green porphyrin.
8. The method of claim 7 wherein said green porphyrin is of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is independently selected from the group consisting of carbalkoxyl (2-6 C), alkyl (1-6 C), arylsulfonyl (6-10 C), cyano and --CONR.sup.5 CO-- wherein R.sup.5 is aryl (6-10 C) or alkyl (1-6 C);
each R.sup.3 is independently carboxyl, carboxyalkyl (2-6 C) or a salt, amide, ester or acyl hydrazone thereof, or is alkyl (1-6 C);
R.sup.4 is CH.dbd.CH.sub.2 or --CH(OR.sup.4')CH.sub.3 wherein R.sup.4' is H, or alkyl (1-6 C) optionally substituted with a hydrophilic substituent.
9. The method of claim 8 wherein said green porphyrin is of the formula ##STR2## wherein each of R.sup.1 and R.sup.2 is independently carbalkoxyl (2-6 C); one R.sup.3 is carboxyalkyl (2-6 C) and the other R.sup.3 is the ester of a carboxyalkyl (2-6 C) substituent; and
R.sup.4 is CH.dbd.CH.sub.2 or --CH(OH)CH.sub.3.
10. The method of claim 9 wherein said green porphyrin is of the formula ##STR3## and wherein R.sup.1 and R.sup.2 are methoxycarbonyl;
one R.sup.3 is --CH.sub.2 CH.sub.2 COOCH.sub.3 and the other R.sup.3 is CH.sub.2 CH.sub.2 COOH; and
R.sup.4 is CH.dbd.CH.sub.2; i.e., BPD-MA.
11. The method of claim 1 wherein said formulation contains said photoactive agent complexed with low-density lipoprotein.
12. The method of claim 1 wherein said formulation is a liposomal preparation.
13. The method of claim 1 wherein said subject has been diagnosed with age-related macular degeneration (AMD).
14. The method of claim 1 wherein the subject has been diagnosed with a condition selected from the group consisting of macular degeneration, ocular histoplasmosis syndrome, myopia, and inflammatory diseases.
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