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Claims for Patent: 5,747,510

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Claims for Patent: 5,747,510

Title: Pharmaceutical unit dosage formulations
Abstract:A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s): Draper; Michael W. (Carmel, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/788,984
Patent Claims: 1. A pharmaceutical formulation in daily dosage unit form comprising, per daily dosage unit, an amount within the range of about 55 to about 150 mg of a compound of formula I ##STR3## or a pharmaceutically acceptable salt or solvate thereof, said formulation in dosage unit form being adapted for oral administration in the form of a capsule or tablet.

2. A pharmaceutical formulation of claim 1 in a form adapted for administration to inhibit bone loss.

3. A pharmaceutical formulation of claim 1 in a form adapted for administration to lower serum cholesterol or.

4. A pharmaceutical formulation of claim 1 in the form of a capsule.

5. A pharmaceutical formulation of claim 1 in the form of a tablet.

6. A pharmaceutical formulation of claim 1 in the form of a suspension.

7. A pharmaceutical formulation of claim 1 wherein the dosage unit comprises 60 mg of a compound of formula I.

8. A pharmaceutical formulation of claim 1 wherein the dosage unit comprises 75 mg of a compound of formula I.

9. A pharmaceutical formulation of claim 1 wherein the dosage unit comprises 100 mg of a compound of formula I.

10. A pharmaceutical formulation of claim 1 wherein the dosage unit comprises 125 mg of a compound of formula I.

11. A pharmaceutical formulation of claim 1 wherein the dosage unit comprises 150 mg of a compound of formula I.

12. A pharmaceutical formulation of claim 1 wherein said formulation is in the form of a capsule.

13. A pharmaceutical formulation of claim 12 wherein the dosage unit comprises 60 mg of a compound of formula I.

14. A pharmaceutical formulation of claim 12 wherein said formulation is adapted for inhibiting bone loss or bone resorption, or lowering serum lipid levels.
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