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Claims for Patent: 5,747,504

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Claims for Patent: 5,747,504

Title: Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors
Abstract:The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
Inventor(s): Henning; Rainer (Hattersheim am Main, DE), Urbach; Hansjorg (Kronberg/Taunus, DE), Teetz; Volker (Hofheim am Taunus, DE), Geiger; Rolf (Frankfurt am Main, DE), Scholkens; Bernward (Kelkheim, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:08/709,286
Patent Claims: 1. A method for treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of an angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor having the formula I: ##STR6## in which R is hydrogen, methyl, ethyl or benzyl; or a pharmaceutically acceptable salt thereof.

2. A method of treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor being N-(1-S-carboxy-3-phenyl-propyl)-S-alanyl-S-1,2,3,4-tetrahydroisoquinoline- 3-carboxylic acid or a pharmaceutically acceptable salt thereof.

3. The method according to claim 1, wherein said inhibitor or salt thereof is administered orally or parenterally.
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