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Claims for Patent: 5,739,152

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Claims for Patent: 5,739,152

Title: Pharmaceutical emulsion
Abstract:A pharmaceutical emulsion for intravenous administration is disclosed which comprises a) a short acting dihydropyridine compound; b) a lipid phase; c) an emulsifier and d) water or a buffer.
Inventor(s): Andersson; Kjell Hjalmar (Fjar.ang.s, SE), Byrod; Eva Kristina (Molndal, SE), Hansson; Anna-Carin (Goteborg, SE), Nordlander; Margareta (Askim, SE), Westerlund; Rolf Christer (Molndal, SE)
Assignee: Astra Aktiebolag (Sodertalje, SE)
Application Number:08/364,953
Patent Claims: 1. A pharmaceutical formulation which is an emulsion for intravenous administration and which comprises

a) a short-acting dihydropyridine compound having a half-life in plasma of less than 30 minutes;

b) a lipid phase;

c) an emulsifier; and

d) water or a buffer.

2. A formulation according to claim 1, wherein the short-acting dihydropyridine compound is selected from the group consisting of 1,4-dihyro-pyridine compounds of the formula I: ##STR3## or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano and trifluoromethyl, and R.sub.3 and R.sub.4 are independently selected from straight or branched lower (1-5 carbon atoms) alkyl groups, provided that when R.sub.3 is methyl and R.sub.4 is tert.-butyl, then R.sub.1 /R.sub.2 are not hydrogen/hydrogen, hydrogen/2'-trifluoromethyl or 2'-chloro/3'-chloro, and when R.sub.3 is methyl and R.sub.1 /R.sub.2 are hydrogen/3'-nitro, then R.sub.4 is not methyl, ethyl, propyl, iso-propyl or tert.-butyl.

3. A formulation according to claim 1, wherein the short-acting dihydropyridine compound is selected from the group consisting of

Acetoxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat e;

Propionoxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat e;

Butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat e;

(4S) -Butyroxymethyl methyl 4- (2',3'-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;

(4R)-Butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat e and

iso-Butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat e.

4. A formulation according to claim 1, wherein the short-acting dihydropyridine compound is present in an amount of 0.001-20 per cent by weight of the entire emulsion weight.

5. A formulation according to claim 1, wherein the lipid phase is selected from the group consisting of triglycerides.

6. A formulation according to claim 1, wherein the lipid phase is present in an amount of 1-35 per cent by weight of the entire emulsion weight.

7. A formulation according to claim 1, wherein the emulsifier is a phospholipid.

8. A formulation according to claim 1, wherein the emulsifier is present in an amount of 0.01-2 times by weight of the amount of the lipid phase.

9. A method for short-term lowering of the blood pressure during surgery and postoperatively in a patient whereby a therapeutically active amount of a formulation according to claim 1 is administered intravenously to the patient.

10. A pharmaceutical formulation for use in the short-term lowering of blood pressure in a patient in need thereof comprising

a) a short acting dihydropyridine compound having a half-life in plasma of less than 30 minutes;

b) a lipid phase;

c) an emulsifier; and

d) water or a buffer.
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