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Claims for Patent: 5,738,872

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Claims for Patent: 5,738,872

Title: Pharmaceutical composition for piperidinoalkanol compounds
Abstract:The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient.
Inventor(s): Ortyl; Thomas T. (Overland Park, KS), Skultety; Paul F. (Leawood, KS), Mitchell; Kristen C. (Lee's Summit, MO), Phadke; Deepak S. (Olathe, KS), Attarchi; Faraneh (Kansas City, MO), Pierce; Marquerite L. (Fairway, KS), Schoeneman; Aaron W. (Lee's Summit, MO), Schnitz; Joseph M. (Kansas City, MO)
Assignee: Hoechst Marion Roussel, Inc. (Cincinnati, OH)
Application Number:08/742,166
Patent Claims: 1. A pharmaceutical composition prepared by a wet granulation process comprising, preparing the wet granulation wherein a compound of formula; ##STR10## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, a diluent and a disintegrant are mixed with a solution of a binding agent; the wet granulation is screened, the wet granulation is dried, and the dry granulation is screened.

2. A pharmaceutical composition prepared by a wet granulation process comprising, preparing the wet granulation wherein a compound of formula; ##STR11## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, a diluent and a disintegrant are mixed with a solution of a binding agent; the wet granulation is screened, the wet granulation is dried and the dry granulation is combined with a lubricant.

3. A pharmaceutical composition in solid unit dosage form prepared by a process comprising blending together a compound of the formula; ##STR12## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, with microcrystalline cellulose, calcium carbonate and pregelatinized starch; adding a solution of gelatin in water with mixing; drying the granulated mixture; adding additional microcrystalline cellulose and sodium starch glycolate with blending; and adding magnesium stearate with blending.

4. A pharmaceutical composition in solid unit dosage form according to claim 3 wherein the final mixture is pressed into tablets.

5. A pharmaceutical composition in solid unit dosage form according to claim 3 wherein the microcrystalline cellulose, calcium carbonate, pregelatinized starch, gelatin, sodium starch glycolate and magnesium stearate are combined in total amounts of about 34.9%, 15.6%, 29.4%, 3.3%, 5.6% and 0.5%, respectively, by weight of the composition.

6. A pharmaceutical composition in solid unit dosage form prepared by a process comprising blending together a compound of the formula; ##STR13## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, with microcrystalline cellulose, calcium carbonate and pregelatinized starch; adding water with mixing; drying the granulated mixture; adding additional microcrystalline cellulose and sodium starch glycolate, with blending; and adding magnesium stearate with blending.

7. A pharmaceutical composition in solid unit dosage form according to claim 6 wherein the final mixture is pressed into tablets.

8. A pharmaceutical composition in solid unit dosage form according to claim 6 wherein the microcrystalline cellulose, calcium carbonate, pregelatinized starch, sodium starch glycolate and magnesium stearate are combined in total amounts of about 336.5%, 15.6%, 31.0%, 5.6% and 0.5%, respectively, by weight of the composition.

9. A pharmaceutical composition in solid unit dosage form, comprising;

a) a therapeutically effective amount of a piperidinoalkanol compound of the formula; ##STR14## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof; and

b) inert ingredients, comprising microcrystalline cellulose, pregelatinized starch, gelatin, magnesium stearate, calcium carbonate and sodium starch glycolate.

10. The pharmaceutical composition in solid unit dosage form according to claim 9 wherein microcrystalline cellulose, pregelatinized starch, gelatin, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 20% to about 85%, 5% to about 50%, 1% to about 15%, 0.05% to about 3%, 5% to about 50% and 1% to about 15%, respectively, by weight of the composition.

11. The pharmaceutical composition in solid unit dosage form according to claim 9 wherein microcrystalline cellulose, pregelatinized starch, gelatin, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 34.9%, 29.4%, 3.3%, 0.5%, 15.6%, 5.6%, respectively, by weight of the composition.

12. A pharmaceutical composition in solid unit dosage form, comprising;

a) a therapeutically effective amount of a piperidinoalkanol compound of the formula; ##STR15## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof; and

b) inert ingredients comprising microcrystalline cellulose, pregelatinized starch, magnesium stearate, calcium carbonate and sodium starch glycolate.

13. The pharmaceutical composition in solid unit dosage form according to claim 12 wherein microcrystalline cellulose, pregelatinized starch, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 20% to about 85%, 5% to about 50%, 0.05% to about 3%, 5% to about 50% and 1% to about 15%, respectively, by weight of the composition.

14. The pharmaceutical composition in solid unit dosage form according to claim 12 wherein microcrystalline cellulose, pregelatinized starch, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 36.5%, 31.0%, 0.5%, 15.6%, and 5.6%, respectively, by weight of the composition.

15. The pharmaceutical composition in solid unit dosage form according to claim 12 wherein microcrystalline cellulose, pregelatinized starch, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 21.1%, 30.0%, 0.75%, 15.6%, and 10.0%, respectively, by weight of the composition.

16. The pharmaceutical composition in solid unit dosage form as in either claims 11, 14 or 15 wherein said piperidinoalkanol compound is 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.al pha.-dimethylbenzeneacetic acid hydrochloride.

17. The pharmaceutical composition in solid unit dosage form according to claim 16 wherein 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.al pha.-dimethylbenzeneacetic acid hydrochloride is present in an amount of about 5 mg to about 180 mg.

18. A pharmaceutical composition in solid form wherein microcrystalline cellulose, pregelatinized starch, magnesium stearate, calcium carbonate and sodium starch glycolate are present in amounts of about 21.1%, 30.0%, 0.75%, 15.6%, and 10.0%, respectively, by weight of the composition wherein the final mixture is pressed into a tablet from which the quantity of compound of the formula; ##STR16## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, dissolved in 45 minutes, is not less than 75% of label in 0.001N aqueous hydrochloric acid at about 37.degree. C. and about 50 rpm when measured using USP Apparatus 2.
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