Claims for Patent: 5,736,165

Summary for Patent: 5,736,165

Title:	In-the-eye use of chlorine dioxide-containing compositions
Abstract:	Disclosed are in-the-eye uses of chlorine dioxide-containing compositions as effective ophthalmic antiseptics and as effective ophthalmic surgical irrigants. Surprisingly low concentrations of chlorine dioxide are effective in such applications. In addition, the presently useful compositions are ophthalmically acceptable.
Inventor(s):	Ripley; Paul S. (Irvine, CA), Dziabo; Anthony J. (Lake Forest, CA), Anger; Claude B. (Long Beach, CA)
Assignee:	Allergan (Waco, TX)
Application Number:	08/277,718
Patent Claims:	1. A method of caring for a mammalian eye comprising: applying directly to a mammalian eye an effective, ophthalmically acceptable amount of a composition which includes chlorine dioxide in an amount effective as an antiseptic in said eye, said amount of chlorine dioxide being less than about 50 ppm by weight of said composition. 2. The method of claim 1 wherein said composition is in the form of an aqueous liquid medium. 3. The method of claim 2 wherein said composition has a pH in the range of about 6 to about 10. 4. The method of claim 3 wherein said composition is substantially isotonic. 5. The method of claim 1 which further comprises producing said composition from a precursor composition including a chlorine dioxide precursor component. 6. The method of claim 5 wherein said producing step occurs directly prior to said applying step. 7. The method of claim 5 wherein said composition is substantially free of any component or residue thereof used to promote the production of chlorine dioxide from said chlorine dioxide precursor component. 8. The method of claim 1 wherein said composition includes an amount of chlorine dioxide in the range of about 0.2 to about 15 ppm by weight. 9. The method of claim 1 wherein said composition includes an amount of chlorine dioxide in the range of about 0.5 to about 10 ppm by weight. 10. The method of claim 1 wherein said mammalian eye has a microbial infection and said applying is effective in treating said microbial infection. 11. The method of claim 1 wherein said applying comprises direct topical installation of said composition into said mammalian eye. 12. The method of claim 1 wherein said applying is repeated. 13. A method of irrigating ocular tissue during ophthalmic surgery comprising: administering directly to an area of a mammalian eye undergoing a surgical procedure an amount of a composition effective to irrigate said area, said composition being ophthalmically acceptable and including chlorine dioxide in an antimicrobially effective amount. 14. The method of claim 13 wherein said administering is effective in disinfecting said area. 15. The method of claim 13 wherein said composition is an aqueous liquid medium. 16. The method of claim 15 wherein said composition has a pH in the range of about 6 to about 10. 17. The method of claim 16 wherein said composition is substantially isotonic. 18. The method of claim 13 which further comprises producing said composition from a precursor composition including a chlorine dioxide precursor component. 19. The method of claim 18 wherein said producing step occurs directly prior to said applying step. 20. The method of claim 18 wherein said composition is substantially free of any component or residue thereof used to promote the production of chlorine dioxide from said chlorine dioxide precursor component. 21. The method of claim 13 wherein said composition includes an amount of chlorine dioxide in the range of about 0.05 to about 10 ppm by weight. 22. The method of claim 13 wherein said composition includes an amount of chlorine dioxide in the range of about 0.1 to about 5 ppm by weight.