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Chinese Patent Office
Farmers Insurance
Daiichi Sankyo

Generated: October 18, 2017

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Claims for Patent: 5,716,957

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Claims for Patent: 5,716,957

Title: Method for modifying and resetting the bloodstream prolactin levels of a human subject
Abstract:A process for the long term modification and regulation of lipid and glucose metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these being the hallmarks of noninsulin dependent, or Type II diabetes)--by administration to a vertebrate, animal or human, of a dopamine agonist and a prolactin stimulator. The dopamine agonist and prolactin stimulator are administered in daily dosages, respectively, at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases in body fat deposits result by treatment of an obese species on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean insulin sensitive members of a similar species. The dopamine agonist is administered at the time of, or just after the time of peak plasma prolactin concentration found in lean animals of the same species and the prolactin stimulator is administered at a time just before the plasma prolactin rhythm reaches its peak in lean animals. Insulin resistance, and hyperinsulinemia or hyperglycemia, or both, can also be controlled in humans on a long term basis by treatment corresponding to that of the treatment for obesity. The short term daily injections reset hormonal timing in the neural centers of the brain to produce long term effects.
Inventor(s): Cincotta; Anthony H. (Andover, MA), Meier; Albert H. (Baton Rouge, LA)
Assignee: The Board of Supervisors of Louisiana State and Agricultural and (Baton Rouge, LA) Ergo Research Corporation (Wakefield, RI)
Application Number:08/469,012
Patent Claims: 1. A method for modifying and resetting the bloodstream prolactin levels of a human subject said subject being diagnosed as being at least one of insulin insensitive and diabetic, said method comprising administering to said subject a prolactin-inhibiting compound once a day, within two hours after waking in the morning, in an amount, and for a period of time sufficient to decrease insulin insensitivity and decrease hyperglycemia in said subject.

2. The method of claim 1 wherein the prolactin inhibiting compound is a dopamine agonist.

3. The method of claim 2 wherein the period of time of administration of said dopamine agonist is also sufficient to modify and reset the glucocorticosteroid bloodstream levels of said subject.

4. The method of claim 1 wherein the dopamine agonist is selecting from the group consisting of 6-methyl-8-beta-carbobenzyloxy-aminoethyl-10 alpha-ergoline; 1,6-dimethyl-8-beta-carbobenzyloxy-aminoethyl-10 alpha-ergoline; 8-acylaminoergolenes; ergoeornine; 9,10-dihydroergocomine; bromocriptine, and D-2-halo-6-alkyl-8-substituted ergolines.

5. The method of claim 1 wherein the compound is bromocriptine.

6. The method of claim 2 wherein the compound is bromocriptine.

7. The method of claim 3 wherein the compound is bromocriptine.

8. The method of claim 4 wherein the compound is bromocriptine.
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