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Summary for Patent: 5,710,285
|Title:||Process for preparing 2-substituted benzo[B]thiophene compounds and intermediates thereof|
|Abstract:||The present invention provides useful intermediates for preparing 2-(substituted phenyl)benzothiophenes compounds said intermediates having the structure ##STR1## wherein R.sup.1 ' is --OH, or --OR.sup.3, in which R.sup.3 is a hydroxy protecting group; and Z is bromo, iodo, triflate, or --B(OH).sub.2 with the proviso that when Z is bromo or iodo, R1' is not alkoxy.|
|Inventor(s):||Hauser; Kenneth L. (Greencastle, IN), Palkowitz; Alan D. (Carmel, IN), Sall; Daniel J. (Greenwood, IN), Thrasher; Kenneth J. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
1. A compound of formula IX ##STR24## wherein R.sup.1 IS --OH or --OR.sup.3, in which R.sup.3 is a hydroxy protecting group; and
Z is bromo, iodo, triflate or --B(OH).sub.2 ;
with the proviso that when Z is bromo or iodo, R.sup.1 ' is not alkoxy.
2. A compound according to claim 1 wherein R.sup.1 ' is --OR.sup.3.
3. A compound according to claim 2 wherein R.sup.3 is C.sub.1 -C.sub.4 alkyl.
4. A compound according to claim 3 wherein R.sup.3 is methyl.
5. A compound according to claim 4 wherein Z is --B(OH).sub.2.
6. A compound according to claim 1 wherein Z is bromo.
7. A compound according to claim 1 wherein Z is iodo.
8. A compound according to claim 1 wherein Z is --B(OH).sub.2.
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