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|Title:||Use of levobupivacaine in a patient having depressed myocardial contractility|
|Abstract:||This application relates to methods of using levobupivacaine substantially free of dexbupivacaine for anaesthetic treatment of pain in a patient having depressed myocardial contractility.|
|Inventor(s):||Bardsley; Hazel Judith (Cambridge, GB), Gristwood; Robert William (Cambridge, GB)|
|Assignee:||Chiroscience Limited (Cambridge, GB)|
1. A method for anaesthetic treatment of pain in a human patient having or disposed to having depressed myocardial contractility, said method comprising the administration of an
effective amount of levobupivacaine or a salt thereof, to said patient, wherein said levobupivacaine is substantially free of dexbupivacaine.
2. The method, according to claim 1, wherein the patient is suffering from a condition selected from the group consisting of hypertension, renal disease, a post-myocardial infarct, ischaemia, diabetes, viral infection, and alcohol dependence.
3. The method according to claim 1, wherein the patient has undergone cardiac surgery, multiple organ failure or a valve replacement, or has been fitted with a pacemaker.
4. The method, according to claim 1, wherein the patient is undergoing concomitant therapy with a cardio-depressant drug.
5. The method, according to claim 1, wherein the patient is undergoing concomitant anti-hypertension therapy, by the administration of a Ca.sup.2+ channel blocker.
6. The method, according to claim 1, wherein the patient is undergoing concomitant therapy with a cytotoxic drug.
7. The method, according to claim 1, wherein the levobupivacaine is in at least 90% enantiomeric excess with respect to dexbupivacaine.
8. The method, according to claim 5, wherein said Ca.sup.2+ channel blocker comprises verapamil.
9. The method, according to claim 1, wherein the patient is suffering from, or disposed to, heart failure at level 2, 3, or 4 of the New York Heart Association Scale.
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