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Last Updated: April 25, 2024

Claims for Patent: 5,708,011

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Summary for Patent: 5,708,011

Title:	Use of levobupivacaine in a patient having depressed myocardial contractility
Abstract:	This application relates to methods of using levobupivacaine substantially free of dexbupivacaine for anaesthetic treatment of pain in a patient having depressed myocardial contractility.
Inventor(s):	Bardsley; Hazel Judith (Cambridge, GB), Gristwood; Robert William (Cambridge, GB)
Assignee:	Chiroscience Limited (Cambridge, GB)
Application Number:	08/640,930
Patent Claims:	1. A method for anaesthetic treatment of pain in a human patient having or disposed to having depressed myocardial contractility, said method comprising the administration of an effective amount of levobupivacaine or a salt thereof, to said patient, wherein said levobupivacaine is substantially free of dexbupivacaine. 2. The method, according to claim 1, wherein the patient is suffering from a condition selected from the group consisting of hypertension, renal disease, a post-myocardial infarct, ischaemia, diabetes, viral infection, and alcohol dependence. 3. The method according to claim 1, wherein the patient has undergone cardiac surgery, multiple organ failure or a valve replacement, or has been fitted with a pacemaker. 4. The method, according to claim 1, wherein the patient is undergoing concomitant therapy with a cardio-depressant drug. 5. The method, according to claim 1, wherein the patient is undergoing concomitant anti-hypertension therapy, by the administration of a Ca.sup.2+ channel blocker. 6. The method, according to claim 1, wherein the patient is undergoing concomitant therapy with a cytotoxic drug. 7. The method, according to claim 1, wherein the levobupivacaine is in at least 90% enantiomeric excess with respect to dexbupivacaine. 8. The method, according to claim 5, wherein said Ca.sup.2+ channel blocker comprises verapamil. 9. The method, according to claim 1, wherein the patient is suffering from, or disposed to, heart failure at level 2, 3, or 4 of the New York Heart Association Scale.

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