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Claims for Patent: 5,705,520

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Claims for Patent: 5,705,520

Title: Medicaments
Abstract:The present invention, relates to 3-[2-(dimethylamino)ethyl]-N-methyl-1H-methanesulphonamide sulphate salt (2:1) and pharmaceutically acceptable solvates thereof, and to pharmaceutical compositions containing same. The compound is useful in the treatment of conditions associated with cephalic pain, in particular migraine. The pharmaceutical compositions are particularly useful as intranasal formulations.
Inventor(s): Craig; Joanne (Ware, GB3), Crookes; Derek Leslie (Ware, GB3), Skittrall; Stephen John (Ware, GB3)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:08/651,961
Patent Claims: 1. 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof.

2. A pharmaceutical composition which comprises 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof as active ingredient together with a pharmaceutically acceptable carrier.

3. A pharmaceutical composition as claimed in claim 2 adapted for intranasal administration.

4. A method of treating a human suffering from or susceptible to cephalic pain which comprises administration of an effective amount of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof to the human in need thereof.

5. A method according to claim 4 wherein the 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof is administered intranasally.

6. A method according to claim 4 wherein the 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof is administered in the form of an aqueous solution.

7. A method according to claim 4 wherein the cephalic pain is caused by migraine.
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