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Claims for Patent: 5,698,225

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Claims for Patent: 5,698,225

Title: Pharmaceutical composition
Abstract:A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can be present between the NSAID core and prostaglandin mantle coating.
Inventor(s): Gimet; Rene Antoine (Valbonne, FR), Jinot; Jean Charles (Cagnes-sur Mer, FR), Magnet; Christian (Chanceaux sur Choislle, FR), Maroteaux; Isabelle (Antibes, FR), Nevoux; Francoise M. (Evanston, IL), Scoyer; Roger E. (Jemeppe-sur Sambre, BE), Struthers; Barbara J. (Deerfield, IL)
Assignee: G. D. Searle & Co. (Chicago, IL)
Application Number:08/794,027
Patent Claims: 1. A pharmaceutical composition comprising:

a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent; and

b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol.

2. A method of treating inflammation comprising orally administering to a patient in need of such treatment, a therapeutically effective amount to treat inflammation of a composition comprising

a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent; and

b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol.

3. A pharmaceutical composition as recited in claim 1 further comprising an intermediate coating surrounding the core wherein the intermediate coating comprises an enteric coating.

4. A pharmaceutical composition as recited in claim 1 wherein the prostaglandin mantle coating comprises a stabilized prostaglandin formulation.
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