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Claims for Patent: 5,696,172

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Claims for Patent: 5,696,172

Title: Injectable mesna solutions
Abstract:Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
Inventor(s): Engel; Jurgen (Alzenau, DE), Wolf-Heuss; Elisabeth (Mosbach, DE), Deger; Wolfgang (Frankfurt, DE), Camuglia; Giancarlo (Frankfurt, DE), Sauerbier; Dieter (Werther, DE)
Assignee: ASTA Medica Aktiengesellschaft (Dresden, DE)
Application Number:08/636,821
Patent Claims: 1. An injectable solution having a pH value in the range of between about 7.5 and about 8.5, and comprising mesna, a complexing agent, a pH adjuster and a preservative.

2. The injectable solution as set forth in claim 1, wherein said solution comprises:

about one part by weight mesna;

about 0.00002-about 2.0 parts by weight sodium ethylene diamine tetraacetate as the complexing agent;

about 0.0002-about 2.0 parts by weight sodium hydroxide as the pH adjuster; and

about 0.001-about 30.0 parts by weight benzyl alcohol as the preservative.

3. The injectable solution as set forth in claim 1, wherein said solution comprises:

about one part by weight mesna;

about 0.0001-about 1.0 parts by weight sodium ethylene diamine tetraacetate as the complexing agent;

about 0.0003-about 1.7 parts by weight sodium hydroxide as the pH adjuster; and

about 0.01-about 20.0 parts by weight benzyl alcohol as the preservative.

4. The injectable solution as set forth in claim 1, wherein said solution comprises:

one part by weight mesna;

about 0.0002-about 0.7 parts by weight sodium ethylene diamine tetraacetate as the complexing agent;

about 0.0004-about 1.4 parts by weight sodium hydroxide as the pH adjuster; and

about 0.018-about 12.0 parts by weight benzyl alcohol as the complexing agent.
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