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|Title:||Flavor-masked pharmaceutical compositions|
|Abstract:||The invention relates to flavour-masked pharmaceutical compositions for oral administration, their preparation and their use as medicaments. The new pharmaceutical preparations according to the invention make it possible to administer pharmaceutical active substances having very unpleasant organoleptic properties such as, for example, very bad taste, even in liquid form.|
|Inventor(s):||Pollinger; Norbert (Odenthal, DE), Michaelis; Johannes (Cologne, DE), Benke; Klaus (Kyoto, JP), Rupp; Roland (Leichlingen, DE), Bucheler; Manfred (Overath, DE)|
|Assignee:||Bayer Aktiengesellschaft (Leverkusen, DE)|
|Patent Claims:||1. A pharmaceutical composition containing an active ingredient which is flavour-masked by microcapsulation having a rapid release of an active ingredient and high bioavailability characterized in that the active ingredient is ciprofloxicin and is present as the anhydrate of its base form and contains less than 5% of water in the form of water of crystallization or other water adducts and is present in an oily juice formulation and the capsule walls consist of a coating which comprises a cationic copolymer of dimethylaminoethyl methacrylate and neutral methyacrylic acid esters, neutral methyl ester and/or ethyl ester compounds of polymethacrylic acid; quaternary ammonium compounds of polymethacrylic acid, or ethylcellulose and triethylcitrate and optionally hydroxypropylmethylcellulose and the microcapsules have a size of 10 to 800 .mu.m.|
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