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Claims for Patent: 5,679,376

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Claims for Patent: 5,679,376

Title: Simethicone containing pharmaceutical compositions
Abstract:A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.
Inventor(s): Stevens; Charles A. (Lansdale, PA), Hoy; Michael R. (North Wales, PA), Roche; Edward J. (Paoli, PA)
Assignee: McNeil-PPC, Inc. (Skillman, NJ)
Application Number:08/455,443
Patent Claims: 1. A solid oral dosage form for the treatment of gastrointestinal distress comprising a therapeutically effective amount of a pharmaceutical for the treatment of gastric disorders selected from the group consisting of diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof, and combinations thereof; and

a therapeutically effective amount of simethicone wherein the oral dosage form has a first portion containing the pharmaceutical and a second portion containing simethicone and the first and second portions are separated by a pharmaceutically acceptable polymeric barrier, which is impermeable to simethicone and the pharmaceutical.

2. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises loperamide HCl.

3. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises diphenoxylate.

4. The solid oral dosage form of claim 1 wherein the pharmaceutical comprises loperamide-N-oxide.

5. The solid oral dosage from of claim 1 wherein the barrier comprises a pharmaceutically acceptable film forming polymer.
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