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Claims for Patent: 5,677,331

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Claims for Patent: 5,677,331

Title: Antimalarial compositions
Abstract:The invention relates to a synergistic antimalarial composition which comprises the antimalarial agent benflumetol and also an antimalarial agent from the artemisinine group such as artemether. The composition can be formulated into solid dosage forms such as tablets and is useful for the treatment of drug resistant malaria.
Inventor(s): Zhou; Yiqing (Beijing, CN), Ning; Dianxi (Beijing, CN), Wang; Shufen (Beijing, CN), Ding; Deben (Beijing, CN), Li; Guofu (Beijing, CN), Shan; Chengqi (Beijing, CN), Liu; Guangyu (Beijing, CN)
Assignee: Ciba-Geigy AG (Basel, CH) Institute of Microbiology and Epidemiology, Academy of Military Medical (Beijing, CN)
Application Number:08/216,440
Patent Claims: 1. A pharmaceutical composition to be administered orally to humans, suitable for synergistic action of the combined active components against malaria, which composition consists of a synergistic antimalarially effective amount of a combination of the compound benflumetol of the formula: ##STR3## in fixed combination with the compound artemether of the formula: ##STR4## wherein one of R and R.sub.1 individually represents methoxy, and the other represents hydrogen,

and pharmaceutically acceptable additives.

2. A pharmaceutical composition according to claim 1, which composition consists of a synergistically effective amount of one to ten parts by weight of benflumetol (I) for each part by weight of artemether (II).

3. A pharmaceutical composition according to claim 1, which composition consists of a synergistically effective amount of three to seven parts by weight of benflumetol (I) for each part by weight of artemether (II).

4. A pharmaceutical composition according to claim 1 which composition consists of a synergistically effective amount of five to six parts by weight of benflumetol (I) for each part by weight of artemether (II).

5. A method of treating malaria which comprises administering orally to a human in need of such treatment a synergistic antimalarially effective amount of a combination of benflumetol of formula (I) and artemether of formula (II).
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