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Claims for Patent: 5,674,872

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Claims for Patent: 5,674,872

Title: Treatment of ovarian cancer
Abstract:A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.
Inventor(s): Johnson; Randall Keith (Ardmore, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:08/411,056
Patent Claims: 1. A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the formula: ##STR3## wherein: a) X is hydroxy and R is trimethylammoniummethyl;

b) X is hydroxy and R is N-methylpiperazinylmethyl;

c) X is hydroxy and R is N-methylanilinomethyl;

d) X is hydroxy and R is cyclohexylaminomethyl;

e) X is hydroxy and R is N,N-dimethylaminoethyloxymethyl;

f) X is hydroxy and R is cyclopropylaminomethyl;

g) X is hydroxy and R is morpholinomethyl;

h) X is hydroxy and R is aminomethyl;

i) X is hydroxy and R is cyanomethyl; or

j) X is hydroxy and R is dimethylaminomethyl

or any pharmaceutically acceptable salts, hydrates and solyates thereof; wherein the course of therapy employed is from about 1.0 to about 2.5 mg/m.sup.2 of body surface area per day for about five consecutive days.

2. The method of claim 1 wherein the administration is oral.

3. The method of claim 1 wherein the administration is parenteral.

4. The method of claim 3 wherein the course of therapy employed is from about 1.5 to about 2 mg/m.sup.2 of body surface area per day for about five consecutive days.

5. The method of claim 4 wherein the course of therapy is repeated at least once at about a seven day to about a twenty-eight day interval.

6. The method of claim 3 wherein the administration is via short or long intravenous infusion.

7. The method of claim 6 wherein the administration is via a 30 minute intravenous infusion.

8. The method of claim 6 wherein the administration is via a 24 hour intravenous infusion.

9. The method of claim 6 wherein the compound is topotecan.

10. The method of claim 1 wherein the compound is topotecan.
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