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Generated: April 25, 2018

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Claims for Patent: 5,659,087

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Summary for Patent: 5,659,087
Title: Diarylvinyl sulfoxides
Abstract:The present invention is directed to new diarylvinyl sulfoxides.
Inventor(s): Aikins; James A. (Indianapolis, IN), Zhang; Tony Y. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/478,706
Patent Claims: 1. A compound of the formula ##STR12## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group,

provided R.sub.1 and R.sub.2 are not both hydrogen when R.sub.3 is C.sub.2 -C.sub.10 alkyl or aryl(C.sub.1 -C.sub.10 alkyl), and R.sub.1 is not C.sub.1 -C.sub.4 alkoxy when R.sub.2 is hydrogen and R.sub.3 is C.sub.2 -C.sub.10 alkyl.

2. A compound as claimed in claim 1 wherein:

R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, or arylalkoxy; and

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, or arylalkoxy.

3. A compound as claimed in claim 2 wherein R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl or aryl(C.sub.1 -C.sub.10 alkyl) group.

4. A compound as claimed in claim 3 wherein R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl group.

5. A compound as claimed in claim 4 wherein:

R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkoxy; and

R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkoxy.

6. A compound as claimed in claim 5 wherein R.sub.1 and R.sub.2 are C.sub.1 -C.sub.4 alkoxy.

7. A compound as claimed in claim 6 wherein R.sub.3 is t-butyl.

8. A compound as claimed in claim 5 wherein R.sub.1 and R.sub.2 are methoxy.

9. A compound as claimed in claim 1 of the formula ##STR13## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group,

provided R.sub.1 and R.sub.2 are not both hydrogen when R.sub.3 is C.sub.2 -C.sub.10 alkyl or aryl(C.sub.1 -C.sub.10 alkyl), and R.sub.1 is not C.sub.1 -C.sub.4 alkoxy when R.sub.2 is hydrogen and R.sub.3 is C.sub.2 -C.sub.10 alkyl.

10. A compound as claimed in claim 9 wherein R.sub.1 and R.sub.2 are methoxy, and R.sub.3 is t-butyl.

11. A compound as claimed in claim 1 of the formula ##STR14## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group,

provided R.sub.1 and R.sub.2 are not both hydrogen when R.sub.3 is C.sub.2 C.sub.10 alkyl or aryl(C.sub.1 -C.sub.10 alkyl), and R.sub.1 is not C.sub.1 -C.sub.4 alkoxy when R.sub.2 is hydrogen and R.sub.3 is C.sub.2 -C.sub.10 alkyl.

12. A compound as claimed in claim 11 wherein R.sub.1 and R.sub.2 are methoxy, and R.sub.3 is t-butyl.

13. A compound of the formula ##STR15## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group.

14. A compound as claimed in claim 13 of the formula ##STR16## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group.

15. A compound as claimed in claim 13 of the formula ##STR17## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino; and

R.sub.3 is a thermally-labile or acid-labile C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.10 alkenyl, or aryl(C.sub.1 -C.sub.10 alkyl) group.

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