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Claims for Patent: 5,648,394

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Claims for Patent: 5,648,394

Title: Topical composition for inhibiting hair growth
Abstract:The present invention embraces a topical composition for inhibiting mammalian hair growth, particularly human beard hair growth (including hirsutism), comprising a water-soluble, hair-growth-inhibiting agent dispersed in an oil-in-water emulsion in the form of a lotion or cream. The invention also embraces a method of inhibiting mammalian hair growth by applying an effective amount of the above composition to the skin. The invention further embraces a topical composition for delivering a pharmacological agent to the skin.
Inventor(s): Boxall; Brian Alfred (Berkshire RG11 5EU, GB), Amery; Geoffrey Wilfred (Berkshire RG6 1HN, GB), Ahluwalia; Gurpreet S. (Gaithersburg, MD)
Assignee:
Application Number:08/513,980
Patent Claims: 1. A topical composition for inhibiting mammalian hair growth which comprises about 1 to 20 parts by weight of a water-soluble, hair-growth-inhibiting active agent dispersed in about 99 to 80 parts by weight correspondingly of a vehicle comprising an oil-in-water emulsion of the following components in parts by weight:

2. The composition of claim 1, adjusted to a pH of about 3.5 and optionally comprising a pH buffer.

3. The composition of claim 1, comprising 5 to 15 parts by weight of said active agent dispersed in 95 to 85 parts by weight correspondingly of said vehicle.

4. The composition of claim 3, wherein said vehicle comprises an oil-in-water emulsion of the following components in parts by weight:

5. The composition of claim 3, wherein said vehicle comprises an oil-in-water emulsion of the following components in parts by weight:

6. The composition of claim 1, 2, 3, 4, or 5, wherein said active agent is 2-(difluoromethyl)-2,5-diaminopentanoic acid.

7. A method of inhibiting mammalian hair growth which comprises applying to the skin of a mammal an effective amount of a topical composition according to claim 1, 2, 3, 4, or 5.

8. The method of claim 7, wherein the active agent in said topical composition is 2-(difluoromethyl)-2,5-diaminopentanoic acid.

9. The method of claim 8, wherein said topical composition is applied daily or twice daily at a level sufficient to provide about 10 to about 2000 micrograms of active agent per square centimeter of skin.

10. The method of claim 8, wherein said topical composition is applied to human skin.

11. A topical composition for delivering a water-soluble, pharmacological agent to the skin which comprises about 1 to 20 parts by weight of said water-soluble, pharmacological agent dispersed in about 99 to 80 parts by weight correspondingly of a vehicle comprising an oil-in-water emulsion of the following components in parts by weight:
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