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Claims for Patent: 5,641,790

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Claims for Patent: 5,641,790

Title: Methods of use for inhibiting bone loss and lowering serum cholesterol
Abstract:A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
Inventor(s): Draper; Michael W. (Carmel, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/422,417
Patent Claims: 1. A pharmacuetical formulation in dosage unit form comprising per dosage unit, an amount within the range of about 55 to about 150 mg of a compound of formula I ##STR3## or a pharmaceutically acceptable salt or solvate thereof.

2. A pharmaceutical formulation of claim 1 in a form adapted for administration to inhibit bone loss.

3. A pharmaceutical formulation of claim 1 in a form adapted for administration to lower serum cholesterol or.

4. A pharmaceutical formulation of claim 1 in a form adapted for oral administration.

5. A pharmaceutical formulation of claim 1 in the form of a capsule.

6. A pharmaceutical formulation of claim 1 in the form of a tablet.

7. A pharmaceutical formulation of claim 1 in the form of a suspension.

8. A pharmaceutical formulation of claim 1 wherein the dosage unit is 60 mg.

9. A pharmaceutical formulation of claim 1 wherein the dosage unit is 75 mg.

10. A pharmaceutical formulation of claim 1 wherein the dosage unit is 100 mg.

11. A pharmaceutical formulation of claim 1 wherein the dosage unit is 125 mg.

12. A pharmaceutical formulation of claim 1 wherein the dosage unit is 150 mg.

13. A pharmaceutical formulation in dosage unit form comprising, per dosage unit, an amount within the range of about 60 to about 100 mg of a compound of formula I ##STR4## or a pharmaceutically acceptable salt or solvate thereof.
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