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Claims for Patent: 5,635,172

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Claims for Patent: 5,635,172

Title: Sustained release comfort formulation for glaucoma therapy
Abstract:Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering of intraocular pressure.
Inventor(s): Jani; Rajni (Fort Worth, TX), Harris; Robert G. (Fort Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Application Number:08/396,284
Patent Claims: 1. A sustained release ophthalmic pharmaceutical composition for controlling and lowering intraocular pressure in humans comprising: a therapeutically effective amount of a drug selected from the group consisting of pilocarpine, epinephrine, proepinephrine, norepinephrine, pronorepinephrine, clonidine, p-aminoclonidine and p-acetoamidoclonidine; and an amount of an anionic mucomimetic polymer having carboxylic acid functional groups which comprise from 2 to 7 carbon atoms per functional group and a molecular weight from 50,000 to 6 million; and a cation exchange resin at a concentration of from about 0.05% to 10% by weight, the composition having a pH of from about 3.0 to 8.5.

2. A method of treatment for controlling and lowering intraocular pressure in humans which comprises administering topically to the affected eye a pharmaceutical composition which comprises:

a therapeutically effective amount of a drug selected from the group consisting of pilocarpine, epinephrine, proepinephrine, norepinephrine, pronorepinephrine, clonidine, p-aminoclonidine and p-acetoamidoclonidine; and a amount of an anionic mucomimetic polymer having carboxylic acid functional groups which comprise from 2 to 7 carbon atoms per functional group and a molecular weight from 50,000 to 6 million; and a cation exchange resin at a concentration of from about 0.05% to 10% by weight, the composition having a pH of from about 3.0 to 8.5.
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