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Claims for Patent: 5,633,169

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Claims for Patent: 5,633,169

Title: Measurement of carbon dioxide in blood
Abstract:A method of determining the total carbon dioxide concentration in plasma (TCO.sub.2 plasma) directly from a whole blood sample involves adjusting total carbon dioxide concentration measured in the whole blood sample (TCO.sub.2 whole blood) using a volume dilution factor (VDF) to give a value that is equivalent to TCO.sub.2 plasma.
Inventor(s): Young; Chung C. (Weston, MA), Chien; Jeffrey (Ashland, MA)
Assignee: Nova Biomedical Corporation (Waltham, MA)
Application Number:08/549,028
Patent Claims: 1. A method of determining the total CO.sub.2 concentration in plasma of a whole blood sample, said whole blood sample containing red blood cells and plasma, wherein the fractional volume of said plasma in said whole blood sample comprises a volume dilution factor of said whole blood sample, said method comprising:

(a) loading an uncentrifuged whole blood sample containing red blood cells and plasma into a blood chemistry analyzer including a CO.sub.2 sensor and a hematocrit-measuring station;

(b) measuring the total CO.sub.2 concentration of said uncentrifuged whole blood sample containing red blood cells and plasma with said CO.sub.2 sensor;

(c) measuring the hematocrit of said uncentrifuged whole blood sample containing red blood cells and plasma at said hematocrit-measuring station;

(d) generating the volume dilution factor of said uncentrifuged whole blood sample containing red blood cells and plasma from said hematocrit; and

(e) adjusting the total CO.sub.2 concentration of said uncentrifuged whole blood sample containing red blood cells and plasma using said volume dilution factor to provide the total CO.sub.2 concentration in plasma of said uncentrifuged whole blood sample.

2. The method of claim 1, wherein the total CO.sub.2 concentration of the uncentrifuged whole blood sample is determined by the addition of an acidifying agent to said uncentrifuged whole blood sample to liberate CO.sub.2 gas which is quantified by a detector.

3. The method of claim 2, wherein the acidifying agent is an aqueous solution comprised of an acid more acidic than carbonic acid.

4. The method of claim 3, wherein the acid is citric acid.

5. The method of claim 2, wherein the acidifying agent is an aqueous solution containing sulfuric acid.

6. The method of claim 2, wherein the detector of liberated CO.sub.2 gas is a manometer.

7. The method of claim 2, wherein the detector of liberated CO.sub.2 gas is a pH glass electrode.

8. The method of claim 1, wherein hematocrit is determined by impedance or conductance.
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