.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 5,633,015

« Back to Dashboard

Claims for Patent: 5,633,015

Title: Beads having a core coated with an antifungal and a polymer
Abstract:The present invention is concerned with beads comprising a 25-30 mesh core, a coating of a hydrophilic polymer and an antifungal agent, and a seal outer coating layer; pharmaceutical dosage forms comprising said beads and a method of preparing said beads. Preferred antifungal agents are lipophilic azole antifungals, such as itraconazole and saperconazole.
Inventor(s): Gilis; Paul M. V. (B-2340-Beerse, BE), De Conde ; Valentin F. V. (B-3920-Lommel, BE), Vandecruys; Roger P. G. (B-2260-Westerlo, BE)
Assignee:
Application Number:08/432,188
Patent Claims: 1. A bead comprising:

a) a central, rounded or spherical core;

b) a coating film of a hydrophilic polymer and an antifungal agent selected from the group consisting of itraconazole and saperconazole, and

c) a seal-coating polymer layer, characterized in that the core has a diameter of from about 600 to about 700 .mu.m (25-30 mesh).

2. A bead according to claim 1 comprising by weight based on the total weight of the bead:

a) 20 to 60 percent core material;

b) 25 to 50 percent hydrophilic polymer;

c) 10 to 25 percent antifungal agent; and

d) 2 to 5 percent seal-coating polymer.

3. A bead according to claim 2 wherein the core material is a 25-30 mesh sugar sphere, the hydrophilic polymer is hydroxypropyl methylcellulose and the antifungal agent is itraconazole.

4. A bead according to claim 3 wherein the weight to weight ratio of antifungal agent: hydrophilic polymer is about 1:1 to about 1:2.

5. A bead according to claim 2 wherein the seal-coating polymer is polyethylene glycol.

6. A bead according to claim 2 comprising approximately:

a) 26 to 38 percent sugar;

b) 32 to 33 percent hydroxypropyl methylcellulose 2910 5 mPa.s.;

c) 21 to 22 percent itraconazole; and

d) 3 to 4 percent polyethylene glycol 20000.

7. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 1.

8. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 2.

9. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 3.

10. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 4.

11. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 5.

12. A pharmaceutical dosage form comprising an effective antifungal amount of beads as defined in claim 6.

13. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole or saperconazole in the form of beads as defined in claim 1.

14. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole or saperconazole in the form of beads as defined in claim 2.

15. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole in the form of beads as defined in claim 3.

16. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole in the form of beads as defined in claim 4.

17. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole in the form of beads as defined in claim 5.

18. A pharmaceutical dosage form wherein the dosage form is a hard-gelatin capsule comprising an effective antifungal amount of itraconazole in the form of beads as defined in claim 6.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc