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Claims for Patent: 5,618,948

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Claims for Patent: 5,618,948

Title: Process for preparing an enantiomer of a carbazole derivative
Abstract:A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists. ##STR1##
Inventor(s): Borrett; Gary T. (Stansted, GB2), Kitteringham; John (Hertford, GB2), Porter; Roderick A. (Ashwell, GB2), Shipton; Mark R. (Bishop's Stortford, GB2), Vimal; Mythily (Edmonton, GB2), Young; Rodney C. (Oxford, GB2)
Assignee: SmithKline Beecham p.l.c. (GB2)
Application Number:08/451,846
Patent Claims: 1. A process for preparing (+)-6-carboxamido-3-methylamino-1,2,3,4-tetrahydrocarbazole or a salt, solvate or hydrate thereof which comprises separation of diastereoisomers of a chiral derivative formed by reaction of (.+-.)-6-carboxamido-3-methylamino-1,2,3,4-tetrahydrocarbazole with R-2-pyrrolidone-5-carboxylic acid, by crystallization, or by chromatography.
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