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Claims for Patent: 5,616,603

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Claims for Patent: 5,616,603

Title: Enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
Abstract:A (+)or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
Inventor(s): Borrett; Gary T. (Stansted, GB2), Kitteringham; John (Hertford, GB2), Porter; Roderick A. (Ashwell, GB2), Shipton; Mark R. (Bishop's Stortford, GB2), Vimal; Mythily (Edmonton, GB2), Young; Rodney C. (Oxford, GB2)
Assignee: SmithKline Beecham plc (GB)
Application Number:08/451,898
Patent Claims: 1. (+)-6-Carboxamido-3-methylamino-1,2,3,4-tetrahydrocarbazole or a salt, solvate or hydrate thereof.

2. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole L (+)-tartrate salt (1:1) or a solvate or hydrate thereof.

3. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole D (-)-tartrate salt (1:1) or a solvate or hydrate thereof.

4. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole hemisuccinate (2:1) or a solvate or hydrate thereof.

5. (+)-6-Carboxamido-3-N-methylamino 1,2,3,4-tetrahydrocarbazole methanesulphonate or a solvate or hydrate thereof.

6. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole succinate (1:1) or a solvate or hydrate thereof.

7. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole hydrochloride or a solvate or hydrate thereof.

8. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole hydrobromide or a solvate or hydrate thereof.

9. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole succinate monohydrate.

10. A method of treatment of a condition wherein a 5-HT.sub.1 -like agonist is indicated, which comprises administering to a subject in need thereof an effective amount of the compound of claim 1 or a physiologically acceptable salt, solvate or hydrate thereof.

11. A method of treating migraine, which comprises administering to a subject in need thereof an effective amount of a compound according to claim 1 or a physiologically acceptable salt, solvate or hydrate thereof.

12. A pharmaceutical composition comprising a compound according to claim 1 or a physiologically acceptable salt, solvate or hydrate thereof and a physiologically acceptable carrier.
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