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Claims for Patent: 5,607,690

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Claims for Patent: 5,607,690

Title: External anti-inflammatory and analgesic plaster preparation
Abstract:An external anti-inflammatory and analgesic plaster preparation includes as an active ingredient a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid, with a cyclic organic having the general formula (I): ##STR1## wherein X is a group of the formula --(CH.sub.2)m-- in which m is an integer of 0 or 1 and n is an integer of 2 and a pH value of the preparation is adjusted to a range of 7.3 to 9.0.
Inventor(s): Akazawa; Mitsuji (Kagawa, JP)
Assignee: Teikoku Seiyaku Co., Ltd. (Kagawa, JP) Altergon S.A. (Lugano, CH)
Application Number:08/579,469
Patent Claims: 1. An external anti-inflammatory and analgesic plaster preparation comprising a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid and a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine, a pH adjuster and optionally, pharmaceutically acceptable thickening agents, humectants, fillers, preservatives and cross-linking agents, wherein a pH value of said preparation is adjusted to a range of 7.3 to 9.0.

2. The external plaster preparation of claim 1 wherein the pH value of the preparation is within a range of 7.5 to 8.5.

3. A process for producing an external anti-inflammatory and analgesic plaster preparation, comprising subjecting a composition comprising a salt of diclofenac, 2[2,6-dichlorophenyl)amino]benzene-acetic acid with a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine, a pH adjuster and optionally, pharmaceutically acceptable thickening agents, humectants, fillers, preservatives and cross-linking agents to the steps of incorporating each ingredient, dissolving or dispersing a part or all of the ingredients in water, and kneading one ingredient with other ingredients while adjusting and maintaining a pH of the composition at a range of 7.3 to 9.0 during the step of preparation and then, spreading the resulting product over a support.

4. An external anti-inflammatory and analgesic plaster comprising:

a preparation containing a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid with a cyclic organic base as an active ingredient, said cyclic organic base comprising hydroxyethylpyrrolidine or hydroxyethylpiperidine; a pH adjuster; pharmaceutically acceptable ingredients comprising a thickening agent; a humectant; a filler, a preservative and a cross-linking agent, wherein a pH value of the said preparation is adjusted to a range of 7.3 to 9.0; and

a support on which said preparation is spread.
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