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Claims for Patent: 5,601,843

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Claims for Patent: 5,601,843

Title: Pharmaceutical tablet composition
Abstract:A pharmaceutical composition including a core of an NSAID selected from diclofenac and piroxicam which core is surrounded by a mantle coating of a prostaglandin, wherein an intermediate coating can be present between the NSAID core and prostaglandin mantle coating.
Inventor(s): Gimet; Rene A. (Valbonne, FR), Jinot; Jean C. (Cagnes-sur-Mer, FR), Magnet; Christian (Chanceaux sur Choisille, FR), Maroteaux; Isabelle (Antibes, FR), Nevoux; Francoise M. (Evanston, IL), Scoyer; Roger E. (Jemeppe-sur-Sambre, BE), Struthers; Barbara J. (Deerfield, IL)
Assignee: G. D. Searle & Co. (Chicago, IL)
Application Number:08/276,299
Patent Claims: 1. A pharmaceutical tablet composition comprising:

a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent selected from diclofenac and piroxicam; and

b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol.

2. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises diclofenac.

3. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises piroxicam.

4. A pharmaceutical composition as recited in claim 1 further comprising an intermediate enteric coating surrounding the core.

5. A pharmaceutical composition as recited in claim 1 wherein the NSAID comprises diclofenac from about 25 to 75 mg and the mantle coating comprises a prostaglandin formulation containing an amount of about 200 mcg of misoprostol.

6. A method of treating inflammation comprising orally administering to a patient in need of such treatment, a therapeutically effective amount to treat inflammation of a composition comprising

a. a core consisting of a therapeutically-effective amount of a nonsteroidal anti-inflammatory agent selected from diclofenac and piroxicam; and

b. a mantle coating surrounding the core comprising a therapeutically-effective amount of misoprostol.

7. A method as recited in claim 6 wherein the nonsteroidal anti-inflammatory agent comprises diclofenac.

8. A method as recited in claim 6 wherein the nonsteroidal anti-inflammatory agent comprises piroxicam.

9. A method as recited in claim 6 wherein the NSAID comprises diclofenac from about 25 to 75 mg and the mantle coating comprises a prostaglandin formulation containing an amount of about 200 mcg of misoprostol.

10. A pharmaceutical tablet composition comprising:

a. a core comprising from about 25 to 75 mg of diclofenac sodium;

b. an enteric coating surrounding the core; and

c. a mantle coating surrounding the enteric coating, the mantle coating comprising from about 100 to about 200 .mu.g misoprostol.
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