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Serving leading biopharmaceutical companies globally:

Colorcon
Medtronic
Fuji
Fish and Richardson
Federal Trade Commission
Healthtrust
Chinese Patent Office
UBS
Deloitte
Dow

Generated: January 21, 2018

DrugPatentWatch Database Preview

Claims for Patent: 5,599,794

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Summary for Patent: 5,599,794
Title: Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic
Abstract:The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable antibiotics as well as enhanced bioavailability of the active antibiotic, thus resulting in higher amounts of the active compound in the gastric mucosa due to secretion of weak bases. Both pharmacological effects contribute to drastically increased antimicrobial capacity of acid degradable antibiotics to be used against local infections in the gastrointestinal tract causing gastritis and/or peptic ulcer. The invention also selects to the use of said combination and a process for the preparation thereof.
Inventor(s): Eek; Arne T. (Trosa, SE), Sj ostrand; Sven Erik (S odert alje, SE)
Assignee: Aktiebolaget Astra (Sodertalje, SE)
Application Number:08/051,722
Patent Claims: 1. A synergistic combination comprising from about 1-200 mg omeprazole or a pharmaceutically acceptable salt thereof and from about 250 mg to 10 mg clarithromycin for the treatment of gastritis and peptic ulcer.

2. A method of orally administering an acid degradable antibiotic so as to increase its bioavailability comprising an effective amount of the synergistic combination of claim 1 to a human.

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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Covington
Mallinckrodt
Dow
Fuji
Colorcon
Healthtrust
Express Scripts
US Department of Justice

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