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Claims for Patent: 5,595,978

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Claims for Patent: 5,595,978

Title: Composition and method for treatment of CMV retinites
Abstract:This invention concerns compositions and methods for the treatment of CMV infections. A composition including an antisense oligonucleotide targeted to the IE2 gene of CMV and a pharmaceutically acceptable carrier were used stop progression in CMV retinitis.
Inventor(s): Draper; Kenneth G. (Boulder, CO), Chapman; Sharon K. (Carlsbad, CA), Kisner; Daniel L. (Cardiff, CA)
Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:08/233,711
Patent Claims: 1. A method for treating CMV retinitis comprising administering by intravitreal injection an effective amount of a composition comprising SEQ ID NO: 1 and a pharmaceutically acceptable carrier to an animal having CMV retinitis.

2. The method of claim 1 wherein the pharmaceutically acceptable carrier is a buffered solution.

3. The method of claim 1 wherein the animal is a human.

4. A composition comprising SEQ ID NO: 1 and a pharmaceutically acceptable carrier.

5. A composition comprising SEQ ID NO: 1 and a bicarbonate buffered solution.

6. A method for the treatment of CMV retinitis comprising administering an effective amount of a composition of claim 4 intravitreally in combination with ganciclovir to an animal having CMV retinitis.

7. A method for the treatment of CMV retinitis comprising administering an effective amount of a composition of claim 5 intravitreally in combination with ganciclovir to an animal having CMV retinitis.

8. A method for the treatment of CMV retinitis comprising administering an effective amount of a composition of claim 4 intravitreally in combination with foscarnet to an animal having CMV retinitis.

9. A method for the treatment of CMV retinitis comprising administering an effective amount of a composition of claim 5 intravitreally in combination with foscarnet to an animal having CMV retinitis.
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