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Last Updated: December 16, 2025

Claims for Patent: 5,591,762

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Summary for Patent: 5,591,762

Title:	Benzimidazoles useful as angiotensin-11 antagonists
Abstract:	Disclosed herein are angiotensin-II antagonists of the formula wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R3 is, inter alia, lower alkyl; and, R4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1 -yl]methyl]-biphenyl-2-carboxylic acid.
Inventor(s):	Norbert Hauel, Berthold Narr, deceased, Uwe Ries, Jacobus C. A. van Meel, Wolfgang Wienen, Michael Entzeroth
Assignee:	Boehringer Ingelheim Pharma GmbH and Co KG
Application Number:	US08/457,204
Patent Claims:

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