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Claims for Patent: 5,580,880

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Claims for Patent: 5,580,880

Title: Method for the treatment of xerostomia
Abstract:A method for the treatment of xerostomia not caused by Sjogren's syndrome comprising administering to an affected individual an effective amount of a derivative of spirooxathiolane-quinuclidine.
Inventor(s): Handa; Harumi (Iruma, JP), Takeshita; Yasuyoshi (Utsunomiya, JP)
Assignee: Snow Brand Milk Products Co., Ltd. (Hokkaido, JP)
Application Number:08/466,373
Patent Claims: 1. A method for the treatment of xerostomia not caused by Sjogren's syndrome comprising administering to an affected individual an effective amount of a therapeutic agent comprising a derivative of spirooxathiolane-quinuclidine or an acid addition salt thereof represented by the following formula (I): ##STR3## wherein R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, alkyl, cyclopentyl, cyclohexyl, aryl, diaryl methylol, or alkyl which may be substituted by one or more aryl groups.

2. A method of treatment of xerostomia according to claim 1 wherein said therapeutic agent comprises 2-methylspiro (1,3-oxathiolane-5,3')-quinuclidine hydrochloride represented by the following formula (II): ##STR4##

3. A method of treatment for xerostomia according to claim 2 wherein said therapeutic agent comprises the cis-isomer.
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