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Claims for Patent: 5,578,628

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Claims for Patent: 5,578,628

Title: Medicaments for the treatment of nausea and vomiting
Abstract:The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group; and one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkynyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting.
Inventor(s): Tyers; Michael B. (Welwyn, GB2), Coates; Ian H. (Hertford, GB2), Humber; David C. (Ealing, GB2), Ewan; George B. (Chalfont St. Peter, GB2), Bell; James A. (Melbourn, GB2)
Assignee: Glaxo Group Limited (GB2)
Application Number:07/501,974
Patent Claims: 1. A method of treatment of nausea and vomiting which comprises administering to a human or animal subject in need thereof an effective amount for the treatment of nausea and vomiting of a compound of formula (Ia) ##STR4## wherein R.sup.1a represents a hydrogen atom or a methyl, ethyl, propyl, prop-2-yl, prop-2-enyl or cyclopentyl group; R.sup.3a represents a hydrogen atom; and either R.sup.2a represents a methyl, ethyl, propyl or prop-2-yl group and R.sup.4a represents a hydrogen atom or R.sup.2a represents a hydrogen atom and R.sup.4a represents a methyl or ethyl group or a physiologically acceptable salt or solvate thereof.

2. A method of treatment of nausea and vomiting induced by an anti-cancer drug which is cisplatin, which comprises administering to a human or animal subject in need thereof an effective amount for the treatment of nausea and vomiting of a compound of formula (Ia) ##STR5## wherein R.sup.1a represents a hydrogen atom or a methyl, ethyl, propyl, prop-2-yl, prop-2-enyl or cyclopentyl group; R.sup.3a represents a hydrogen atom; and either R.sup.2a represents a methyl, ethyl, propyl or prop-2-yl group and R.sup.4a represents a hydrogen atom or R.sup.2a represents a hydrogen atom and R.sup.4a represents a methyl or ethyl group or a physiologically acceptable salt or solvate thereof.
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