|Abstract:||Disclosed are solutions useful in surgery comprising a viscous or viscoelastic substance in an aqueous vehicle which is characterized as physiologically compatible; also disclosed are methods of using such solutions, implanting such viscous or viscoelastic substances, while minimizing the traumatic effect of surgery at the cellular level.|
|Inventor(s):||Hecht; Gerald (Fort Worth, TX), Lorenzetti; Ole J. (Fort Worth, TX)|
|Assignee:||Alcon Laboratories, Inc. (Fort Worth, TX)|
1. An ophthalmic solution comprising a therapeutically effective amount of a viscous or viscoelastic material selected from the group consisting of collagen, modified collagen and
modified cellulose and combinations thereof in a physiologically compatible salt solution, the salt solution containing bicarbonate ions.
2. The solution of claim 1 wherein the physiologically compatible salt solution further contains sodium, potassium, calcium, and magnesium ions.
3. The solution of claim 1 wherein the viscous or viscoelastic material comprises hydroxypropylmethylcellulose.
4. The solution of claim 1 wherein the bicarbonate ions are present in a concentration of between about 10 mM/L and about 50 mM/L.