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Claims for Patent: 5,567,817

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Claims for Patent: 5,567,817

Title: Triazole antifungal agents
Abstract:The invention provides antifungal compounds of the formula: ##STR1## and pharmaceutical salts thereof, wherein R is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF.sub.3 and --OCF.sub.3 ; R.sup.1 is C.sub.1 -C.sub.4 alkyl; R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; X is CH or N; and Y is F or Cl.
Inventor(s): Ray; Stephen J. (Deal, GB2), Richardson; Kenneth (Birchington;, GB2)
Assignee: Pfizer Inc. (New York, NY)
Application Number:08/432,414
Patent Claims: 1. A compound of the formula ##STR52## or a pharmaceutically acceptable salt thereof, wherein R is 2,4-difluorophenyl, and R.sup.2 is hydrogen or methyl.

2. A compound of the formula ##STR53## or a pharmaceutically acceptable salt thereof, wherein R is 2,4-difluorophenyl, 2,4-dichlorophenyl, 2-chlorophenyl, 4-fluorophenyl, or 2-fluorophenyl.

3. 2-(2,4-difluo rophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, or a pharmaceutically acceptable salt thereof.

4. (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropy rimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition for treating a fungal infection in a mammal which comprise an effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.

6. A pharmaceutical composition for treating a fungal infection in a mammal which comprises an effective amount of the compound of claim and a pharmaceutically acceptable carrier.

7. A pharmaceutical composition for treating a fungal infection in a mammal which comprises an effective amount of the compound of claim 3 and a pharmaceutically acceptable carrier.

8. A pharmaceutical composition for treating a fungal infection in a mammal which comprises an effective amount of the compound of claim 4 and a pharmaceutically acceptable carrier.

9. A method of treating a fungal infection in a mammal which comprises administering to said mammal an effective amount of the compound of claim 1.

10. A method of treating a fungal infection in a mammal which comprises administering to said mammal an effective amount of the compound of claim 2.

11. A method of treating a fungal infection in a mammal which comprise administering to said mammal an effective amount of the compound of claim 3.

12. A method of treating a fungal infection in a mammal which comprised administering to said mammal an effective amount of the compound of claim 4.
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