Generated: May 29, 2017
|Abstract:||A compound of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or an alkyl group, Z represents a ring selected from: ##STR2## in which n represents 4, 5 or 6; ##STR3## in which R.sup.3 represents hydrogen or an alkyl group and R.sup.4 represents an alkyl, methoxy benzyl or R.sup.5 NHCO group, R.sup.5 being an alkyl group; and ##STR4## in which R.sup.6 represents an alkyl group. and pharmaceutically acceptable salts thereof are useful in the treatment of migraine and other conditions. They are prepares by decarboxylation of the corresponding indolyl 2-carboxylic acid.|
|Inventor(s):||Forner; Dolors F. (Barcelona, ES), Duran; Carles P. (Barcelona, ES), Soto; Jose P. (Barcelona, ES), Noverola; Armando V. (Barcelona, ES), Mauri; Jacinto M. (Barcelona, ES)|
|Assignee:||Laboratorios Almirall S.A. (ES)|
1. A compound of formula (I) ##STR11## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a C.sub.1-6 alkyl group, Z represents a ring selected from: ##STR12## in which n
represents 4, 5 or 6; ##STR13## in which R.sup. 6 represents a C.sub.1-6 alkyl group, or pharmaceutically acceptable salts thereof.
2. A compound according to claim 1 in which R.sup.1 and R.sup.2 which by the same or different is each C.sub.1-4 alkyl, and Z is of the formula II.
1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]-4-ethoxycarbonyl piperazine; or a hydrochloride salt thereof.
4. A composition comprising a compound according to claim 1 mixed with a pharmaceutically acceptable carrier or diluent.
5. A method of treating headaches, movement disorders, depression or anxiety which comprises administering to a human or animal subject in need of treatment of an effective amount of a compound according to claim 1.
6. A method according to claim 5 wherein said treatment is for a migraine.
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