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Generated: December 16, 2017

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Claims for Patent: 5,554,639

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Claims for Patent: 5,554,639

Title: Medicaments
Abstract:3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide sulphate salt (2:1) and pharmaceutically acceptable solvates thereof are disclosed. The compound is of use in the preparation of pharmaceutical compositions, particularly for intranasal formulations, for use in the treatment of conditions associated with cephalic pain, in particular migraine.
Inventor(s): Craig; Joanne (Ware, GB3), Crookes; Derek L. (Ware, GB3), Skittrall; Stephen J. (Ware, GB3)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:08/460,791
Patent Claims: 1. An intranasal pharmaceutical composition for intranasal administration which comprises an aqueous solution containing an intranasally effective amount of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide sulphate salt (2:1) or a physiologically acceptable solvate thereof as active ingredient together with a pharmaceutically acceptable carrier, wherein the aqueous solution has a pH range of 5 to 7.

2. A pharmaceutical composition as claimed in claim 1 which contains the salt in a concentration of 20 mgml.sup.-1 to 500 mgml.sup.-1.

3. A pharmaceutical composition as claimed in claim 1 which is formulated in unit dosage form comprising 0.5 to 100 mg of active ingredient.

4. An intranasal pharmaceutical composition which comprises a sterile aqueous solution of 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide sulphate salt (2:1) or a physiologically acceptable solvate thereof in a concentration of 20 mgml.sup.-1 to 500 mgml.sup.-1, which solution has a pH in the range of pH 5 to pH 7.

5. A method of treating a human suffering from or susceptible to migraine, which comprises intranasally administering the composition of claim 1.

6. A method of treating a human suffering from or susceptible to migraine, which comprises intranasally administering the composition of claim 2.

7. A method of treating a human suffering from or susceptible to migraine, which comprises intranasally administering the composition of claim 3.

8. A method of treating a human suffering from or susceptible to migraine, which comprises intranasally administering the composition of claim 4.

9. A pharmaceutical composition as claimed in claim 4, wherein the solution has a pH in the range of 5.4 to 5.6.
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Novartis
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Teva
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McKinsey
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Citi
Accenture

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