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Claims for Patent: 5,547,948

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Claims for Patent: 5,547,948

Title: Controlled release of steroids from sugar coatings
Abstract:A sugar coating composition for application to a compressed medicinal tablet comprising a sugar, a dose of a hormonal steroid and a steroid release rate controlling amount of microcrystalline cellulose.
Inventor(s): Barcomb; Reginald J. (Mooers Forks, NY)
Assignee: American Home Products Corporation (Madison, NJ)
Application Number:08/373,667
Patent Claims: 1. A compressed tablet comprising a tablet core containing conjugated estrogens and a sugar coating in which said sugar coating incorporates a hormonal steroid and a release rate controlling amount of microcrystalline cellulose.

2. A compressed tablet of claim 1 in which said tablet core contains from about 0.1 to about 5.0 milligrams of conjugated estrogens and said sugar coating contains from about 1.0 to about 50 milligrams of said hormonal steroid.

3. A compressed tablet of claim 1 in which said tablet core contains from about 0.3 to about 2.5 milligrams of conjugated estrogens and said sugar coating contains about 1.5 to about 30 milligrams of medroxyprogesterone acetate.

4. A compressed tablet comprising a tablet core containing conjugated estrogens and a sugar coating in which said sugar coating incorporates with the sugar sucrose, the hormonal steroid medroxyprogesterone acetate and asteroid release rate controlling amount of microcrystalline cellulose.

5. A compressed tablet of claim 4 in which said tablet core contains from about 0.1 to about 5.0 milligrams of conjugated estrogens and said sugar coating contains from about 1 to about 50 milligrams of medroxyprogesterone acetate.

6. A compressed tablet of claim 4 in which said tablet core contains from about 0.3 to about 2.5 milligrams of conjugated estrogens and said sugar coating contains about 2.5 to about 30 milligrams of medroxyprogesterone acetate.
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