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Last Updated: March 26, 2026

Claims for Patent: 5,538,982

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Summary for Patent: 5,538,982

Title:	Medical use for tachykinin antagonists
Abstract:	The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R1 is selected from halogen atoms and C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, and S(O)n C1-4 alkyl groups; R2 and R3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C1-4 alkyl, C1-4 alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.
Inventor(s):	Russell M. Hagan, Keith T. Bunce
Assignee:	Glaxo Group Ltd
Application Number:	US08/269,079
Patent Claims:

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