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Claims for Patent: 5,532,372

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Claims for Patent: 5,532,372

Title: Imide derivatives, and their production and use
Abstract:An imide compound of the formula: ##STR1## wherein Z is a group of the formula: ##STR2## in which the substituents are defined herein, and n is an integer of 0 to 1; D is a group of the formula: in which A is a non-aromatic hydrocarbon ring optionally bridged with a lower alkylene group or an oxygen atom, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and p and q are each an integer of 0, 1 or 2; and Ar is an aromatic group, a heterocyclic aromatic group, a benzoyl group, a phenoxy group or a phenylthio group and G is >N--, >CH-- or >COH-- or Ar is a biphenylmethylidene group and G is >C.dbd., all of the above groups being each optionally substituted with at least one of lower alkyl, lower alkoxy and halogen; and its acid addition salts, useful as an antipsycotic agent.
Inventor(s): Saji; Ikutaro (Osaka, JP), Muto; Masayuki (Osaka, JP), Tanno; Norihiko (Osaka, JP), Yoshigi; Mayumi (Osaka, JP)
Assignee: Sumitomo Pharmaceuticals Company, Ltd. (Osaka, JP)
Application Number:08/113,320
Patent Claims: 1. An imide compound of the formula: ##STR144## wherein Z is a group of the formula: ##STR145## in which B is a carbonyl group or a sulfonyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or an alkyl group having 1-4 carbon atoms with a proviso that R.sup.1 and R.sup.2 or R.sup.1 and R.sup.3 are combined together to make a non-aromatic hydrocarbon ring having at most 7 carbon atoms and being un-substituted or substituted with at least one alkyl group having 1-4 carbon atoms, and n is an integer of 0 or 1;

D is a group of the formula:

in which A is a non-aromatic hydrocarbon ring having at most 7 carbon atoms or a non-aromatic hydrocarbon ring having at most 7 carbon atoms which is bridged with an alkylene group having not more than 3 carbon atoms or an oxygen atom, and p and q are each an integer of 0, 1 or 2;

Ar is a benzisothiazolyl group being unsubstituted or substituted with at least one of an alkyl group having 1-4 carbon atoms, an alkoxy group having 1-4 carbon atoms and a halogen atom; and G is >N--; or an acid addition salt thereof.

2. The imide compound according to claim 1, wherein said non-aromatic hydrocarbon ring in Z is further bridged with an alkylene group having 1-3 carbon atoms and being un-substituted or substituted with at least one alkyl group having 1-4 carbon atoms, or an oxygen atom; or an acid addition salt thereof.

3. The imide compound according to claim 1, wherein said non-aromatic hydrocarbon ring in D is further bridged with an alkylene group having 1-3 carbon atoms and being unsubstituted or substituted with at least one alkyl group having 1-4 carbon atoms, or an oxygen atom; or an acid addition salt thereof.

4. The imide compound according to claim 1, wherein said non-aromatic hydrocarbon rings in Z and D are further bridged with an alkylene group having 1-3 carbon atoms and being unsubstituted or substituted with at least one alkyl group having 1-4 carbon atoms, or an oxygen atom; or an acid addition salt thereof.

5. The imide compound according to claim 1, wherein Z is one of the following formulas: ##STR146## wherein L is --CH.sub.2 --CH.sub.2 --or --CH.dbd.CH--, E is an alkylene group having not more than 3 carbon atoms and being un-substituted or substituted with an alkyl group having not more than 4 carbon atoms or an oxygen atom, R.sup.5 is a hydrogen atom or an alkyl group having not more than 4 carbon atoms and B is a carbonyl group or a sulfonyl group; ##STR147## wherein L, E, R.sup.5 and B are each as defined above; ##STR148## wherein R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 are each a hydrogen atom or an alkyl group having not more than 4 carbon atoms, or two of those present at the neighboring positions each other may be combined together to make a bond and B is as defined above; and ##STR149## wherein R.sup.4 is a hydrogen atom or an alkyl group having not more than 4 carbon atoms, R.sup.16 and R.sup.17 are combined together to make a saturated hydrocarbon ring having not more than 7 carbon atoms, and B is as defined above; or an acid addition salt thereof.

6. An imide compound of the formula: ##STR150## wherein Z is a group of the formula: ##STR151## wherein L is --CH.sub.2 --CH.sub.2 --or --CH.dbd.CH--, E is an alkylene group having not more than 3 carbon atoms;

D is a group of the formula:

wherein A is a cycloalkane ring having not more than 7 carbon atoms or a cycloalkane ring having not more than 7 carbon atoms which is bridged with an alkylene group having not more than 3 carbon atoms, or an oxygen atom, p and q are each an integer of 0, 1 or 2;

Ar is a benzisothiazolyl group; and

G is >N--

or an acid addition salt thereof.

7. The imide compound according to claim 7, wherein said cycloalkane ring in D is further bridged with an alkylene group having 1-3 carbon atoms; or an acid addition salt thereof.

8. The imide compound according to claim 7 or 8, wherein Z is a group of the formula: ##STR152## wherein E is a methylene group or an ethylene group; or an acid addition salt thereof.

9. The imide compound according to claim 7 or 8, wherein D is a group of the formula:

wherein A is as defined above; or an acid addition salt thereof.

10. The imide compound according to claim 10, wherein A is a cyclohexane ring; or an acid addition salt thereof.

11. The imide compound of the formula: ##STR153## wherein Z is a group of the formula: ##STR154## wherein E is a methylene group or an ethylene group; D is a group of the formula:

wherein A is a cycloalkane ring having not more than 7 carbon atoms or a cycloalkane ring having not more than 7 carbon atoms which is bridged with an alkylene group having not more than 3 carbon atoms, or an oxygen atom;

Ar is a benzisothiazolyl group; and

G is >N--; or an acid addition salt thereof.

12. The imide compound according to claim 14, wherein E is a methylene group; or an acid addition salt thereof.

13. The imide compound according to claim 14 or 15, wherein A is a 1,2-cyclohexane-diyl group; or an acid addition salt thereof.

14. The imide compound of the formula: ##STR155## or an acid addition salt thereof.

15. The imide compound of the formula: ##STR156##

16. The imide compound of one of the following formulae: ##STR157##

17. The imide compound of the formula: ##STR158## or an acid addition salt thereof.

18. The imide compound of the formula: ##STR159## or an acid additional salt thereof.

19. The imide compound of the formula: ##STR160## or an acid addition salt thereof.

20. The imide compound according to claim 1, wherein said non-aromatic hydrocarbon ring and said alkylene group in the definition of A are each substituted with at least one alkyl group having 1-4 carbon atoms.
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