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Claims for Patent: 5,532,246

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Claims for Patent: 5,532,246

Title: Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B
Abstract:Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed. ##STR1##
Inventor(s): Belleau, deceased; Bernard (late of Westmont, CA), Nguyen-Ba; Nghe (La Prairie, CA)
Assignee: BioChem Pharma, Inc. (Laval, CA)
Application Number:08/084,222
Patent Claims: 1. A method for the treatment of a mammal, including a human, suffering from hepatitis B infection, comprising administration of an effective amount of a compound of formula (I) ##STR5## or a pharmaceutically acceptable salt, ester, or salt of an ester thereof to said mammal.

2. The method according to claim 1 wherein the hepatitis B infection is human hepatitis B.

3. The method according to claim 1 wherein the compound of formula (I) comprises (+)-cis-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-o ne or a pharmaceutically acceptable salt, ester, or salt of an ester thereof.

4. The method according to claim 1 wherein the compound of formula (I) comprises (-)-cis-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-o ne or a pharmaceutically acceptable salt, ester, or salt of an ester thereof.

5. The method according to claim 4 wherein the compound of formula (I) is substantially free of the corresponding (+)-enantiomer.

6. The method according to any one of claims 1 to 5 wherein the compound of formula (I) is adapted for oral administration.

7. The method according to any one of claims 1 to 5 wherein the compound of formula (I) is adapted for parenteral administration.

8. The method according to any one of claims 1 to 5 wherein the compound of formula (I) is in unit dosage form.

9. The method according to claim 8 wherein the compound is present in an amount of from 10 to 1500 mg.
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