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Claims for Patent: 5,527,814

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Claims for Patent: 5,527,814

Title: Use of 2-amino-6-(trifluoromethoxy)benzothiazole for obtaining a medicament for the treatment of amyotrophic lateral sclerosis
Abstract:Use of 2-amino-6-(trifluoromethoxy)benzothiazole, or a salt of this compound with a pharmaceutically acceptable acid, for obtaining a medicament intended for the treatment of motor neuron diseases, in particular amyotrophic lateral sclerosis, and especially amyotrophic lateral sclerosis with early bulbar involvement or the bulbar form of the disease.
Inventor(s): Louvel; Erik (Manosque, FR)
Assignee: Rhone Poulenc Rorer S.A. (FR)
Application Number:08/327,343
Patent Claims: 1. A method for treating a mammal with amyotrophic lateral sclerosis, comprising the step of administering to said mammal in recognized need of said treatment an effective amount of 2-amino-6-(trifluoromethoxy)benzothiazole or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 wherein said amyotrophic lateral sclerosis is with early bulbar involvement.

3. The method according to claim 1 wherein said amyotrophic lateral sclerosis is the bulbar form.

4. The method according to claim 1, wherein said effective amount comprises 25 to 200 mg of said 2-amino-6-(trifluoromethoxy)benzothiazole or said salt thereof.

5. The method according to claim 4, wherein said effective amount comprises 50 mg.

6. The method according to claim 4, wherein said effective amount comprises 25 mg.

7. The method according to claim 1, wherein said effective amount comprises 50 to 400 mg of said 2-amino-6-(trifluoromethoxy)benzothiazole or said salt thereof.

8. The method according to claim 4, wherein said effective amount comprises 200 mg.

9. The method according to claim 1, wherein said effective amount comprises 400 mg.

10. The method according to claim 1, wherein said 2-amino-6-(trifluoromethoxy)benzothiazole or said salt thereof is administered along with a pharmaceutically acceptable carrier.

11. The method according to claim 1, wherein said 2-amino-6-(trifluoromethoxy)benzothiazole or said salt thereof is administered along with a pharmaceutically compatible product.

12. The method according to claim 4, wherein said effective amount comprises 100 mg.

13. The method according to claim 1, wherein said pharmaceutically acceptable salt is an acid addition salt.
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