Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Accenture
Fish and Richardson
US Department of Justice
Farmers Insurance
Queensland Health
Cerilliant
Deloitte
Baxter

Generated: May 23, 2018

DrugPatentWatch Database Preview

Claims for Patent: 5,514,826

« Back to Dashboard

Summary for Patent: 5,514,826
Title: Vinyl sulfenic acid derivatives
Abstract:The present invention is directed to novel vinyl sulfenic acid derivatives, useful for the synthesis of benzo[b]thiophenes, in particular 2-arylbenzo[b]thiophenes.
Inventor(s): Hoard; David W. (Lafayette, IN), Luke; Wayne D. (West Lafayette, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/483,607
Patent Claims: 1. A compound of the formula ##STR16## wherein: R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, arylalkoxy, halo, or amino;

R.sub.4 is OSi(R).sub.3, NR.sub.5 R.sub.6, or SR.sub.8 ;

each R is independently C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl;

R.sub.5 and R.sub.6 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, arylalkyl, or aryl; or R.sub.5 and R.sub.6 together with the nitrogen atom form a ring selected from piperidine, pyrrolidine, morpholine, or hexamethylimine; and

R.sub.8 is C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl.

2. The compound of claim 1 wherein:

R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkoxy, or arylalkoxy; and

R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkoxy, or arylalkoxy.

3. The compound of claim 2 wherein:

R.sub.4 is OSi(R).sub.3 ; and

each R is independently C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl.

4. The compound of claim 3 wherein R.sub.4 is OTMS, OTES, OTIPS, ODMIPS, ODEIPS, OTDS, OTBDMS, OTBDPS, OTBS, OTPS, ODPMS, or OTBMPS.

5. The compound of claim 4 wherein R.sub.4 is OTMS, OTES, ODMIPS, ODEIPS, OTBDMS, OTBS, or OTPS.

6. The compound of claim 5 wherein R.sub.1 and R.sub.2 are C.sub.1 -C.sub.4 alkoxy.

7. The compound of claim 6 wherein R.sub.1 and R.sub.2 are methoxy, and R.sub.4 is OTMS.

8. The compound of claim 2 wherein:

R.sub.4 is NR.sub.5 R.sub.6 ; and

R.sub.5 and R.sub.6 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, arylalkyl, or aryl; or R.sub.5 and R.sub.6 together with the nitrogen atom form a ring selected from piperidine, pyrrolidine, morpholine, and hexamethylimine.

9. The compound of claim 8 wherein R.sub.5 and R.sub.6 are independently hydrogen, C.sub.1 -C.sub.6 alkyl, or arylalkyl; or R.sub.5 and R.sub.6 together with the nitrogen atom form a ring selected from piperidine and pyrrolidine.

10. The compound of claim 9 wherein R.sub.1 and R.sub.2 are C.sub.1 -C.sub.4 alkoxy.

11. The compound of claim 10 wherein R.sub.1 and R.sub.2 are methoxy, and R.sub.5 and R.sub.6 are methyl.

12. The compound of claim 10 wherein R.sub.1 and R.sub.2 are methoxy, R.sub.5 is hydrogen, and R.sub.6 is benzyl.

13. The compound of claim 2 wherein:

R.sub.4 is SR.sub.8 ; and

R.sub.8 is C.sub.1 -C.sub.6 alkyl, aryl, or arylalkyl.

14. The compound of claim 13 wherein R.sub.8 is C.sub.1 -C.sub.6 alkyl or arylalkyl.

15. The compound of claim 14 wherein R.sub.8 is C.sub.1 -C.sub.6 alkyl.

16. The compound of claim 15 wherein R.sub.1 and R.sub.2 are C.sub.1 -C.sub.4 alkoxy.

17. The compound of claim 16 wherein R.sub.1 and R.sub.2 are methoxy, and R.sub.8 is ethyl.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Mallinckrodt
Medtronic
Baxter
AstraZeneca
Healthtrust
QuintilesIMS
Cipla
Fish and Richardson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.