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Last Updated: December 12, 2025

Claims for Patent: 5,504,207

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Summary for Patent: 5,504,207

Title:	Process and intermediate for the preparation of terazosin hydrochloride dihydrate
Abstract:	A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate.
Inventor(s):	Anthony Mannino, Rodger F. Henry, Wayne R. Heitmann, Bruce W. Horrom
Assignee:	Abbott Laboratories
Application Number:	US08/324,635
Patent Claims:

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