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Claims for Patent: 5,502,077

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Claims for Patent: 5,502,077

Title: Fatty acid composition
Abstract:Fatty acid composition comprising at least 80% by weight of omega-3-fatty acids, salts or derivatives thereof, wherein (all-Z)-5,8,11,14,17-eicosapentaenoic acid (EPA) and (all-Z)-4,7,10,13,16,19-docosahexaenoic acid comprises at least 75% by weight of the total fatty acids. The compositions can be used for the treatment or prophylaxis of multiple risk factors for cardiovascular diseases.
Inventor(s): Breivik; Harald (Skjelsvik, NO), Borretzen; Bernt (Porsgrunn, NO), Dahl; Knut H. (Ulefoss, NO), Krokan; Hans E. (Sjetnemarka, NO), Bonaa; Kaare H. (Tromso, NO)
Assignee: Norsk Hydro A.S. (Oslo, NO)
Application Number:07/902,500
Patent Claims: 1. A method for the treatment or prophylaxis of hypertriglyceridemia in a human patient, which comprises orally administering to the patient a pharmaceutical composition in which the active ingredients consist essentially of a mixture of fatty acids of which at least 80% by weight is comprised of a combination of (all-Z omega-3)-5,8,11,14,17-eicosapentaenoic acid (EPA) and (all-Z omega-3)-4,7,10,13,16,19-docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 1:2 to 2:1, said composition being administered in amounts providing a daily dosage of 1 to 10 grams of said mixture of fatty acids.

2. The method of claim 1, wherein at least 85% by weight of the mixture of fatty acids is comprised of long chain omega-3 fatty acids.

3. The method of claim 2, wherein the EPA constitutes 40 to 60% by weight of the mixture of fatty acids and the DHA constitutes 25 to 45% by weight of the mixture of fatty acids.

4. The method of claim 3, wherein the EPA and DHA are present in the composition in an EPA:DHA weight ratio of from 1:1 to 2:1.

5. The method of claim 4, wherein at least 4.5% by weight of the mixture of fatty acids is comprised of fatty acids other than EPA and DHA that have 20, 21, or 22 carbon atoms.

6. The method of claim 4, wherein at least 3% by weight of the mixture of fatty acids is comprised of omega-3 fatty acids other than EPA and DHA that have 20, 21, or 22 carbon atoms.

7. The method of claim 4, wherein at least 1% by weight of the mixture of fatty acids is comprised of (all-Z omega-3)-6,9,12,15,18-heneicosapentaenoic acid.

8. The method of any of claims 5, 6, or 7, wherein the fatty acids are present in the composition in esterified form.

9. The method of any of claims 5, 6, or 7, wherein the fatty acids are present in the composition in ethyl ester form.

10. The method of any of claims 5, 6, or 7, wherein the fatty acids are present in the composition in salt form.

11. The method of any of claims 5, 6, or 7, wherein the fatty acids are present in the composition in the free acid form.

12. The method of claim 7, wherein at least 85% by weight of the fatty acid content of the composition is comprised of the combination of EPA and DHA, and the fatty acids are present in the composition in ethyl ester form.
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